{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T01:47:46Z","timestamp":1770515266675,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T00:00:00Z","timestamp":1568764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["81571430"],"award-info":[{"award-number":["81571430"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["81701433"],"award-info":[{"award-number":["81701433"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["81871154"],"award-info":[{"award-number":["81871154"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hyperactivity of the sympathetic nervous system was considered as one of the factors involved in the pathological mechanisms of premature ejaculation (<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>). Sympathetic skin response of the penis (<jats:styled-content style=\"fixed-case\">PSSR<\/jats:styled-content>) was used to evaluate the activity of sympathetic innervations in the penis, which was controlled by the central nervous system (brain). Shorter <jats:styled-content style=\"fixed-case\">PSSR<\/jats:styled-content> was found in <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> patients; however, little was known regarding the central neural mechanisms of <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> patients with high sympathetic activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PSSR<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> patients was evaluated, and diffusion tensor images of\u00a0participants were collected. Graph theoretical analysis was employed to examine the differences of the topological properties of structural brain connectome between <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> patients with high sympathetic activity and healthy controls (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>s). Moreover, the relationships between topological characteristics and clinical features in <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> patients were also explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Decreased local efficacy was found in the left amygdala, right pallidum and thalamus in the white matter brain networks of <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> when compared with <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> (survived false discovery rate (<jats:styled-content style=\"fixed-case\">FDR<\/jats:styled-content>) correction). In addition, <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> patients showed decreased global efficacy in the left amygdala and right rolandic operculum, supramarginal gyrus, heschl gyrus, inferior temporal gyrus, pallidum and thalamus; however, these results did not survive <jats:styled-content style=\"fixed-case\">FDR<\/jats:styled-content> correction. Finally, the local efficacy of right thalamus had a positive correlation with the premature ejaculation diagnostic tool (<jats:styled-content style=\"fixed-case\">PEDT<\/jats:styled-content>) scores, while the local efficacy of left amygdala was negatively associated with the state score of the state\u2010trait anxiety inventory (<jats:styled-content style=\"fixed-case\">STAI<\/jats:styled-content>) and penile shaft sensory threshold.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results highlighted the abnormal topological properties of structural brain connectome in <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> with high sympathetic activity. We also suggested that the clinical features of <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> were related to the abnormality of several brain regions involved in the central control of ejaculation and emotion. This study provided new insights into the central neural mechanisms of <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>, which might offer biological markers for understanding the physiopathology of <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.12701","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T12:41:22Z","timestamp":1568810482000},"page":"400-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Graph analysis of <scp>DTI<\/scp>\u2010based connectome: decreased local efficiency of subcortical regions in <scp>PE<\/scp> patients with high sympathetic activity"],"prefix":"10.1111","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0389-4049","authenticated-orcid":false,"given":"J.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Andrology Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Andrology Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Andrology Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Andrology Nanjing Drum Tower Hospital Affiliated Hospital of Nanjing University Medical School Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nanjing Brain Hospital Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Andrology Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2017.01.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.08.033"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1103-13.2013"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22138"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.12.028"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24819"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.178002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2017.1387116"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2018.00157"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12546"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI89519"},{"key":"e_1_2_7_13_1","first-page":"2029","article-title":"Amygdala Response to Emotional Stimuli without Awareness: Facts and Interpretations","volume":"7","author":"Diano M","year":"2016","journal-title":"Front Psychol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-01-00349.2001"},{"key":"e_1_2_7_15_1","article-title":"Premature ejaculation: an update on definition and pathophysiology","author":"El\u2010Hamd MA","year":"2019","journal-title":"Asian J Androl"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2018.07.012"},{"key":"e_1_2_7_17_1","first-page":"190","article-title":"Neuroanatomy and physiology of ejaculation","volume":"16","author":"Giuliano F","year":"2005","journal-title":"Annu Rev Sex Res"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25808"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-004-0484-y"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-27-09185.2003"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2007.00734.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-018-1984-9"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/00224490902747230"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.05.025"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10508-007-9208-x"},{"key":"e_1_2_7_26_1","first-page":"81","article-title":"Brain areas activated after ejaculation in healthy young human subjects","volume":"51","author":"Mallick HN","year":"2007","journal-title":"Indian J Physiol Pharmacol"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00408-7"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.07.021"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2017.03.002"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10508-007-9236-6"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.22655"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.003"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2015.252"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsn030"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23859"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10128"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4927(03)00068-4"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2014.02.005"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1037\/bne0000026"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12654"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijir.2013.23"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.4103\/aja.aja_4_18"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00448"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2018.00206"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00421-3"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/andr.12701","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T06:25:31Z","timestamp":1693895131000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.12701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,18]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/andr.12701"],"URL":"https:\/\/doi.org\/10.1111\/andr.12701","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,18]]},"assertion":[{"value":"2019-06-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}