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In men, non\u2010obstructive azoospermia (<jats:styled-content style=\"fixed-case\">NOA<\/jats:styled-content>) results from defects in the spermatogenic process that can be attributed to spermatogonial stem cells (<jats:styled-content style=\"fixed-case\">SSC<\/jats:styled-content>) or their niche, or both. While assisted reproductive technologies and sperm banking can enable fertility preservation (<jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>) in men of reproductive age who are at risk for infertility, <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content> for pre\u2010pubertal patients remains experimental. Therapeutic options for <jats:styled-content style=\"fixed-case\">NOA<\/jats:styled-content> are limited. The rapid advance of stem cell research and of gene editing technologies could enable new <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content> options for these patients. Induced pluripotent stem cells (<jats:styled-content style=\"fixed-case\">iPSC<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">SSC<\/jats:styled-content>, and testicular niche cells, as well as mesenchymal stromal cells (aka medicinal signaling cells, <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s), have been investigated for their potential use in male <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content> strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Here, we review the benefits and challenges for three types of stem cell\u2010based approaches under investigation for male <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>, focusing on the role that promising sources of <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content> derived from human umbilical cord, specifically human umbilical cord perivascular cells (<jats:styled-content style=\"fixed-case\">HUCPVC<\/jats:styled-content>), could fulfill. These approaches are as follows: 1. isolation and <jats:italic>ex vivo<\/jats:italic> expansion of autologous <jats:styled-content style=\"fixed-case\">SSC<\/jats:styled-content> for <jats:italic>in vivo<\/jats:italic> transplantation or <jats:italic>in vitro<\/jats:italic> spermatogenesis; 2. <jats:italic>in vitro<\/jats:italic> differentiation toward germ cell and testicular somatic cell lineages using autologous <jats:styled-content style=\"fixed-case\">SSC<\/jats:styled-content>, or stem cells such <jats:styled-content style=\"fixed-case\">iPSC<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>; and 3. protection or regeneration of the spermatogenic niche after gonadotoxic insults <jats:italic>in vivo<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our studies suggest that <jats:styled-content style=\"fixed-case\">HUCPVC<\/jats:styled-content> are promising sources of cells that could be utilized in multiple aspects of male <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content> strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.12713","type":"journal-article","created":{"date-parts":[[2019,9,28]],"date-time":"2019-09-28T02:16:04Z","timestamp":1569636964000},"page":"862-878","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Potential use of stem cells for fertility preservation"],"prefix":"10.1111","volume":"8","author":[{"given":"A.","family":"Gauthier\u2010Fisher","sequence":"first","affiliation":[{"name":"CReATe Fertility Centre Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kauffman","sequence":"additional","affiliation":[{"name":"CReATe Fertility Centre Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9699-4059","authenticated-orcid":false,"given":"C. 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