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Pre\u2010mature ejaculation patients exhibit altered brain activation and abnormal cortical structures. However, there has been no research evaluating the topological organization of structural brain network in anejaculation (<jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We employed diffusion tensor imaging data and graph theory to examine the whole\u2010brain structural networks among 16 <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content> patients and 23 healthy controls. In addition, the results of sexual function assessment were also obtained from each patient for symptom assessment. Moreover, the relationships between these clinical features and the altered topological characteristics of <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content> patients were also explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Decreased clustering coefficient was found in the right amygdala, inferior temporal gyrus, and left pallidum of <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content> also showed increased path length in the right post\u2010central gyrus, supramarginal gyrus, putamen, pallidum and left heschl gyrus, temporal pole (superior temporal gyrus); however, these altered brain regions showed no significant differences after false discovery rate correction. Moreover, the path length between subcortical and frontal regions was increased in <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>. In addition, negative correlations were found between the altered nodal parameters and the amplitudes of somatosensory evoked potentials of dorsal nerve, sympathetic skin response located in the penis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Together, our results suggest that <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content> was associated with disruptions in the topological organization of structural brain networks. The decreased clustering coefficient in temporal and subcortical regions and the increased path length between subcortical and frontal regions may contribute to <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>. These findings provide new insights into the pathophysiological mechanisms of <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.12715","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T18:20:13Z","timestamp":1571077213000},"page":"392-399","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Reduced segregation and integration of structural brain network associated with sympathetic and dorsal penile nerve activity in anejaculation patients: a graph\u2010based connectome study"],"prefix":"10.1111","volume":"8","author":[{"given":"J.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Andrology Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing 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