{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:00:15Z","timestamp":1791644415776,"version":"4.3.4"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The term<jats:italic>Late\u2010onset hypogonadism<\/jats:italic>(LOH) was coined in 2002 and defined as a disease entity in the ISA, ISSAM, EAU, EAA and ASA endorsed Recommendations for Investigation, Treatment and Monitoring of LOH (2005 and 2008) as \u2018a clinical<jats:italic>and<\/jats:italic>biochemical syndrome associated with advancing age, characterized by symptoms<jats:italic>and<\/jats:italic>a deficiency in serum testosterone (T)\u2019. LOH was classified as a combined primary and secondary hypogonadism since the endocrine capacity of the testes and the pituitary are impaired. Symptoms of LOH include loss of libido, erectile dysfunction, loss of muscle mass, increased body fat, anemia, osteoporosis, depressed mood, decreased vitality, sweating, and hot flushes. Since these symptoms may also have origins other than LOH, exclusion of other disease entities and subnormal serum T levels are considered prerequisites for the diagnosis and possible treatment of LOH. However, during following years these guidelines were often neglected and, especially in the USA, indiscriminate prescribing of T was widely practised so that the US FDA warned against such irresponsible behavior. In Europe, T prescribing remained largely restricted to LOH as defined above. Nevertheless, a discussion started whether LOH really exists or is only a consequence of age\u2010related comorbidities. Numerous studies have helped to clarify the situation, in particular, the European Male Aging Study (EMAS) and the US\u2010initiated<jats:italic>7\u00a0T trials<\/jats:italic>. Consequently, the newest US Endocrine Society Practice Guideline on T treatment (2018) includes advanced age as a cause of organic hypogonadism and recommends that \u2018in men &gt;65\u00a0years who have symptoms or conditions suggestive of T deficiency \u2026 and consistently and unequivocally low morning T concentrations we suggest that clinicians offer T therapy on an individualised basis after explicit discussion of the potential risks and benefits\u2019. Thus, the concept of LOH as conceived two decades ago has weathered criticism and survived the times.<\/jats:p>","DOI":"10.1111\/andr.12719","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T20:21:39Z","timestamp":1571775699000},"page":"1506-1511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Late\u2010onset hypogonadism: a concept comes of age"],"prefix":"10.1111","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1403-3298","authenticated-orcid":false,"given":"E.","family":"Nieschlag","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine and Andrology University of M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031719"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/003335491513000207"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028014539918"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.7999"},{"key":"e_1_2_8_6_1","first-page":"42","article-title":"\u00dcber die Transplantation der Hoden","author":"Berthold AA","year":"1849","journal-title":"Archiv f\u00fcr Anatomie Physiologie und Wissenschaftliche Medicin"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-00229"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)64118-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1515\/bchm2.1935.237.1-3.89"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2014.950653"},{"key":"e_1_2_8_11_1","first-page":"196","article-title":"Is late\u2010onset hypogonadotropic hypogonadism a specific age\u2010dependent disease, or merely an epiphenomenon caused by accumulating disease\u2010burden?","volume":"41","author":"Corona G","year":"2016","journal-title":"Minerva Endocrinol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2002.tb05014.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1515\/bchm2.1935.233.5-6.281"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12952"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2015.11.003"},{"key":"e_1_2_8_16_1","unstructured":"DohleGR ArverS BettocchiC KlieschS PunabM &de RondeW. 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