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Increasing levels of heavy metals and the use of organophosphate pesticides (OPs) and their co\u2010existence in the environment could be associated with an increasing incidence of male reproductive system disorders in humans and animals. <jats:italic>Ferulago angulata<\/jats:italic> is a dietary source of phenolic compounds with reported health benefits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study was conducted to investigate whether an extract of <jats:italic>Ferulago angulata<\/jats:italic> could protect adult male NMRI mice against reproductive toxicity induced by lead acetate (PbAc), diazinon (DZN), or PbAc\u00a0+\u00a0DZN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Adult male NMRI mice were exposed to either 0.5% PbAc in drinking water, DZN (3\u00a0mg\/kg\/day, intraperitoneal [i.p.] injection), or PbAc\u00a0+\u00a0DZN in the presence or absence of 400\u00a0mg\/kg\/day <jats:italic>Ferulago angulata<\/jats:italic> hydroalcoholic extract (FAE) that was administered via gavage for 6\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Chronic exposure to PbAc, DZN, and PbAc\u00a0+\u00a0DZN decreased sperm quality, sperm chromatin maturity and integrity, increased oxidative stress and lipid peroxidation, and could reduce male fertility indices. Co\u2010administration of FAE could reduce these negative effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:italic>Ferulago angulata<\/jats:italic> extract should be considered as a useful natural extract for the treatment of male infertility, especially in males exposed to conditions which induce reproductive toxicity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.12730","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T13:36:23Z","timestamp":1574256983000},"page":"706-718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["<i>Ferulago angulata<\/i> extract ameliorates epididymal sperm toxicity in mice induced by lead and diazinon"],"prefix":"10.1111","volume":"8","author":[{"given":"Nushin","family":"Naderi","sequence":"first","affiliation":[{"name":"Department of Animal Science College of Agriculture Razi University Kermanshah Iran"},{"name":"Department of Reproductive Biotechnology Reproductive Biomedicine Research Center Royan Institute for Biotechnology ACECR Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manouchehr","family":"Souri","sequence":"additional","affiliation":[{"name":"Department of Animal Science College of Agriculture Razi University Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1983-3435","authenticated-orcid":false,"given":"Mohammad Hossein","family":"Nasr Esfahani","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biotechnology Reproductive Biomedicine Research Center Royan Institute for Biotechnology ACECR Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Hajian","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biotechnology Reproductive Biomedicine Research Center Royan Institute for Biotechnology ACECR Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Tanhaei Vash","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biotechnology Reproductive Biomedicine Research Center Royan Institute for Biotechnology ACECR Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,5]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"10","article-title":"Effect of low\u2010dose lead on semen quality and sperm's DNA integrity in adult male mice","volume":"8","author":"Al\u2010Juboori BM","year":"2013","journal-title":"Reproduction"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.238.295"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2014.10.010"},{"key":"e_1_2_9_5_1","first-page":"301","article-title":"Effect of oral administration of lead acetate on some biochemical and hormonal parameters during pregnancy in Baladi Goats","volume":"2","author":"El\u2010Hameed ARA","year":"2008","journal-title":"Global Veterinaria"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-008-9088-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2007.04.024"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2015.10.017"},{"key":"e_1_2_9_9_1","first-page":"8","article-title":"Lead reproductive toxicity and modulator role of mango wastes extracts in mice","volume":"5","author":"Aida EL Makawy","year":"2015","journal-title":"Int J Dev Res"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2013.10.001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.09.003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2009.09.008"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2016.05.002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-016-0177-6"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-015-5519-y"},{"key":"e_1_2_9_16_1","article-title":"Apoptotic effect of organophosphorus insecticide diazinon on rat ovary and protective effect of vitamin E. 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