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Taking a paternal perceptive, recent research has shown that sperm epigenetics, such as changes in DNA methylation, histone modification, chromatin structure, and noncoding RNA expression, can impact reproductive and offspring health. Importantly, environmental conditions during the preconception period has been demonstrated to shape sperm epigenetics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To provide an overview on epigenetic modifications that regulate normal gene expression and epigenetic remodeling that occurs during spermatogenesis, and to discuss the epigenetic alterations that may occur to the paternal germline as a consequence of preconception environmental conditions and exposures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>We examined published literature available on databases (PubMed, Google Scholar, ScienceDirect) focusing on adult male preconception environmental exposures and sperm epigenetics in epidemiologic studies and animal models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The preconception period is a sensitive developmental window in which a variety of exposures such as toxicants, nutrition, drugs, stress, and exercise, affects sperm epigenetics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Conclusion<\/jats:title>\n                    <jats:p>Understanding the environmental legacy of the sperm epigenome during spermatogenesis will enhance our understanding of reproductive health and improve reproductive success and offspring well\u2010being.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.12753","type":"journal-article","created":{"date-parts":[[2020,1,4]],"date-time":"2020-01-04T12:05:10Z","timestamp":1578139510000},"page":"924-942","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":134,"title":["The preconception environment and sperm epigenetics"],"prefix":"10.1111","volume":"8","author":[{"given":"Chelsea","family":"Marcho","sequence":"first","affiliation":[{"name":"Department of Environmental Health Sciences School of Public Health and Health Sciences University of Massachusetts Amherst Amherst Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oladele A.","family":"Oluwayiose","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences School of Public Health and Health Sciences University of Massachusetts Amherst Amherst Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4541-6267","authenticated-orcid":false,"given":"J. 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