{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:28:31Z","timestamp":1790116111161,"version":"4.0.1"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T00:00:00Z","timestamp":1579651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Functional hypogonadism is a common disorder among patients with obesity and type 2 diabetes mellitus and could be managed by first treating the underlying causes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The present study was undertaken to investigate the contribution of body weight and glycemic control to the reversibility of hypogonadism to eugonadism in a real\u2010life setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Adult obese male patients with uncontrolled type 2 diabetes mellitus, complaining of mild to moderate erectile dysfunction and suspected of functional hypogonadism evaluated at our institution from 2015 to 2017, were retrospectively included. The gonadal status 3 and 12\u00a0months after the glucose\u2010lowering medication prescription was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy\u2010one consecutive patients were enrolled, with 24 (34%) of them achieving total testosterone \u2265300\u00a0ng\/dL (10.4\u00a0nM\/L) at the end of the study. When they were stratified according to HbA1c and body weight loss, a direct correlation was found for the latter only. Particularly, 94% of patients achieving a body weight loss &gt;10% presented with total testosterone \u2265300\u00a0ng\/dL. An inverse correlation was found for HbA1c, with no higher prevalence of total testosterone \u2265300\u00a0ng\/dL in patients with HbA1c &lt;6.5%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The findings are strengthened by the rigorous study design. However, a limited number of patients and glucose\u2010lowering medications could be included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present study supports the hypothesis that in obese patients with uncontrolled type 2 diabetes mellitus losing weight may have a greater impact on androgens compared to improving glycemic control. Further prospective studies are needed to corroborate this finding.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.12754","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:50:20Z","timestamp":1578617420000},"page":"654-662","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Weight loss more than glycemic control may improve testosterone in obese type 2 diabetes mellitus men with hypogonadism"],"prefix":"10.1111","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7073-1795","authenticated-orcid":false,"given":"Vito Angelo","family":"Giagulli","sequence":"first","affiliation":[{"name":"Section of Internal Medicine Geriatrics, Endocrinology and Rare Disease Interdisciplinary Department of Medicine School of Medicine University of Bari Bari Italy"},{"name":"Outpatients Clinic of Endocrinology and Metabolic Disease Conversano Hospital Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1175-8998","authenticated-orcid":false,"given":"Marco","family":"Castellana","sequence":"additional","affiliation":[{"name":"National Institute of Gastroenterology \u201cS. De Bellis\u201d, Castellana Grotte Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo Domenico","family":"Carbone","sequence":"additional","affiliation":[{"name":"Institute of Clinical and Hormonal Research Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6390-2146","authenticated-orcid":false,"given":"Carla","family":"Pelusi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Center for Applied Biomedical Research Department of Medical and Surgical Sciences Alma Mater Studiorum S. Orsola\u2010Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Isabella","family":"Ramunni","sequence":"additional","affiliation":[{"name":"Outpatients Clinic of Endocrinology and Metabolic Disease Conversano Hospital Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0020-3273","authenticated-orcid":false,"given":"Giovanni","family":"De Pergola","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Human Oncology University of Bari Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Guastamacchia","sequence":"additional","affiliation":[{"name":"Section of Internal Medicine Geriatrics, Endocrinology and Rare Disease Interdisciplinary Department of Medicine School of Medicine University of Bari Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6308-0528","authenticated-orcid":false,"given":"Vincenzo","family":"Triggiani","sequence":"additional","affiliation":[{"name":"Section of Internal Medicine Geriatrics, Endocrinology and Rare Disease Interdisciplinary Department of Medicine School of Medicine University of Bari Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1796"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22579"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00116"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.5.1821"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-00229"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-3580"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0262"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3132\/dvdr.2008.022"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183369"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-2388"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-S009"},{"key":"e_1_2_9_13_1","unstructured":"Associazione Medici Diabetologi (AMD) Societ\u00e0 Italiana di Diabetologia (SID).Standard italiani per la cura del diabete mellito.2018.http:\/\/www.siditalia.it\/pdf\/Standard%20di%20Cura%20AMD%20-%20SID%202018_protetto.pdf. 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