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This article aims to provide the latest evidence for the efficacy and safety of traditional Chinese medicine (TCM) combined with vitamins in the treatment of male infertility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>All randomized controlled trials (RCTs) that used TCM combined with vitamins for male infertility treatment were included in databases of China National Knowledge Infrastructure (CNKI), Wanfang, VIP Database, China Biology Medicine disc (CBM), MEDLINE, EMBASE, and Cochrane Library. The quality of the included articles was evaluated using the Cochrane Reviewer's Handbook 5.3, and meta\u2010analysis was performed using Stata 15.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 14 eligible studies with 1488 patients were included in this meta\u2010analysis. The results suggested that, compared with vitamin E or vitamin E\u00a0+\u00a0C alone, combination of TCM with vitamins increased significantly sperm concentration, sperm motility, sperm viability, liquefaction time of semen, the activity of acrosome enzyme, and the pregnancy rate of patients with male infertility. Three kinds of TCM (Shengjing capsule, Huanshao capsule, and compound Xuanju capsule) showed significant improvement for male infertility in terms of pregnancy rate, sperm concentration, or sperm motility. In addition, the results of the publication bias test demonstrated that no significant bias occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Traditional Chinese medicine combined with vitamins has significant efficacy in the treatment of male infertility with no increase in side effects. The specific implementing regulations still need more long\u2010term, multicenter, randomized, and double\u2010blind clinical trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.12787","type":"journal-article","created":{"date-parts":[[2020,3,14]],"date-time":"2020-03-14T07:44:45Z","timestamp":1584171885000},"page":"1038-1050","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Vitamins combined with traditional Chinese medicine for male infertility: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3821-7032","authenticated-orcid":false,"given":"Ming","family":"Wang","sequence":"first","affiliation":[{"name":"Fuyang People's Hospital Anhui Medical University Fuyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Renji Hospital Shanghai Jiao Tong 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