{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:53:33Z","timestamp":1790744013610,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T00:00:00Z","timestamp":1589587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the influence of a multi\u2010component nutrient dietary supplement on sperm parameters and pregnancy rates in idiopathic male infertility (IMI) with oligo\u2010, astheno\u2010, and teratozoospermia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A randomized, double\u2010blind, placebo\u2010controlled, prospective, parallel arms (1:1 allocation ratio), multi\u2010center clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Settings<\/jats:title><jats:p>Eight urology\/reproductive health clinical centers located in Ukraine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Eighty\u2010three males aged 21\u201050\u00a0years with IMI and at least 1 of 3 abnormal values: total sperm concentration\u00a0&lt;\u00a015 million\/ml or\/and spermatozoa progressive motility\u00a0&lt;\u00a032% or\/and forms with normal morphology\u00a0&lt;\u00a04%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Intervention(s)<\/jats:title><jats:p>Patients were randomly allocated verum test dietary supplement (TDS) containing <jats:sc>l<\/jats:sc>\u2010carnitine\/acetyl\u2010<jats:sc>l<\/jats:sc>\u2010carnitine, <jats:sc>l<\/jats:sc>\u2010arginine, glutathione, co\u2010enzyme Q10, zinc, vitamin B<jats:sub>9<\/jats:sub>, vitamin B<jats:sub>12<\/jats:sub>, selenium, or placebo 1 time daily for 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome(s)<\/jats:title><jats:p>The primary outcome measure was the percentage of normal spermiograms (concentration\u00a0\u2265\u00a015 million\/ml and\u00a0\u2265\u00a032% of spermatozoa with progressive motility and\u00a0\u2265\u00a04% of normal forms) at month 0, 2, and 4. The percentage of pregnancies served the secondary outcome endpoint. Differences between the groups were assessed in z\u2010test for proportions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All males finished the study. At month 4, 29\/42 (69.0%) males in the verum and 9\/41 (22.0%) had normal spermiograms (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). The percentage of spontaneous pregnancies in the verum group was greater than in the placebo group (10\/42, 23.8% vs. 2\/41, 4.9%, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.017). There were no reportable supplement\u2010associated adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Specific multi\u2010nutrient combination <jats:sc>l<\/jats:sc>\u2010carnitine\/<jats:sc>l<\/jats:sc>\u2010acetyl\u2010carnitine, <jats:sc>l<\/jats:sc>\u2010arginine, glutathione, co\u2010enzyme\u2010Q, zinc, folic acid, cyanocobalamin, and selenium can improve sperm quality in males with IMI and increase pregnancy rates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.12805","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T19:11:40Z","timestamp":1587755500000},"page":"1184-1193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Dietary supplementation with a novel <scp>l<\/scp>\u2010carnitine multi\u2010micronutrient in idiopathic male subfertility involving oligo\u2010, astheno\u2010, teratozoospermia: A randomized clinical study"],"prefix":"10.1111","volume":"8","author":[{"given":"Roman","family":"Kopets","sequence":"first","affiliation":[{"name":"Medical Center \"Astar\" Lviv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Kuibida","sequence":"additional","affiliation":[{"name":"Precarpathian Center of Reproductive Health Ivano\u2010Frankivsk Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iryna","family":"Chernyavska","sequence":"additional","affiliation":[{"name":"Mykolaiv State Clinical Hospital Mykolaiv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasyl","family":"Cherepanyn","sequence":"additional","affiliation":[{"name":"Lviv State Center for the Reproductive Health Lviv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Mazo","sequence":"additional","affiliation":[{"name":"Private Urologic Practice Mykolaiv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitaliy","family":"Fedevych","sequence":"additional","affiliation":[{"name":"Lviv State Hospital Lviv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9712-9905","authenticated-orcid":false,"given":"Sergiy","family":"Gerasymov","sequence":"additional","affiliation":[{"name":"MedianaStatistics Lviv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,16]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Manual for the standardized investigation and diagnosis of the infertile couple","author":"WHO","year":"2000"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2605.2000.00250.x"},{"key":"e_1_2_6_4_1","unstructured":"JungwirthA DiemerT DohleGR et al.Guidelines on male infertility. 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