{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T06:38:22Z","timestamp":1792305502291,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Preliminary published data depict a much greater prevalence of males with laboratory\u2010confirmed severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) referred for intensive care unit admission and severe sequelae in several countries. In this context, males seem to not only be more susceptible to the infection compared to female subjects, at least in Western countries, but their case fatality rate attributable to SARS\u2010CoV\u20102 infection is also highest. Therefore, we may speculate that the different hormonal milieu could have a more profound pathophysiological role in association with SARS\u2010CoV\u20102, with endogenous testosterone leaving men more prone to develop more serious complications related to the SARS\u2010CoV\u20102 infection. Another option is that SARS\u2010CoV\u20102 infection per se causes an acute stage of male hypogonadism, the depletion of androgenic action triggering serious or an even fatal course of the disease. Therefore, we strongly advocate the development of a prospective multidimensional andrological translational research project in men, which we called the PROTEGGIMI study. In this <jats:italic>Opinion Article,<\/jats:italic> we will not only highlight novel research activity in this area but also invite other researchers and learned scientific societies to join us in our efforts to understand an important and very newly discovered gap in knowledge, which may have serious implications for the lives of millions of men.<\/jats:p>","DOI":"10.1111\/andr.12811","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T19:59:02Z","timestamp":1588708742000},"page":"19-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["SARS\u2010CoV\u20102, testosterone and frailty in males (PROTEGGIMI): A multidimensional research project"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0595-7165","authenticated-orcid":false,"given":"Andrea","family":"Salonia","sequence":"first","affiliation":[{"name":"University Vita\u2010Salute San Raffaele Milan Italy"},{"name":"Division of Experimental Oncology\/Unit of Urology URI IRCCS Ospedale San Raffaele Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9894-2885","authenticated-orcid":false,"given":"Giovanni","family":"Corona","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Ospedale Maggiore Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5816-0785","authenticated-orcid":false,"given":"Aleksander","family":"Giwercman","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine Lund University Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3267-4221","authenticated-orcid":false,"given":"Mario","family":"Maggi","sequence":"additional","affiliation":[{"name":"Endocrinology Unit Department of Experimental, Clinical and Biomedical Sciences \"Mario Serio\" University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6516-619X","authenticated-orcid":false,"given":"Suks","family":"Minhas","sequence":"additional","affiliation":[{"name":"Department of Urology Charing Cross Hospital Imperial College Healthcare NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5216-9882","authenticated-orcid":false,"given":"Rossella E.","family":"Nappi","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Section of the Department of Clinical, Surgical, Diagnostic and Pediatric Sciences Research Center for Reproductive Medicine Gynecological Endocrinology and Menopause IRCCS Policlinico S. Matteo University of Pavia Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1528-4029","authenticated-orcid":false,"given":"Nikolaos","family":"Sofikitis","sequence":"additional","affiliation":[{"name":"Department of Urology University of Ioannina School of Medicine Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0907-0630","authenticated-orcid":false,"given":"Linda","family":"Vignozzi","sequence":"additional","affiliation":[{"name":"Andrology, Female Endocrinology and Gender Incongruence Unit Department of Experimental, Clinical and Biomedical Sciences \"Mario Serio\" University of Florence Florence 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