{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:22:39Z","timestamp":1789176159645,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","award":["114S792"],"award-info":[{"award-number":["114S792"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Resistin is known as a potential mediator of obesity\u2010associated insulin resistance. The high resistin level disrupts nitric oxide (NO)\u2010mediated relaxation which is also important in erectile function. An antioxidant alkaloid, Boldine, is known as anti\u2010diabetic and protects endothelial functions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to investigate resistin expression in penile tissue in the presence of insulin resistance (IR) and the effect of\u00a0<jats:italic>Boldine<\/jats:italic>\u00a0treatment on erectile functions in the metabolic syndrome (MetS) rat model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Wistar rats were randomly divided into three groups: Control, MetS, and boldine treated MetS group. MetS parameters were assessed by serum triglycerides (TG), uric acid (UA), glucose, insulin levels, HOMA index, and waist circumference (WC)\/tibia length (TL) ratio. To evaluate erectile functions, intracavernous pressure (ICP)\/mean arterial pressure (MAP) ratio was performed during cavernous nerve stimulation. Protein expressions of resistin, endothelial nitric oxide synthase (eNOS), p(S1177) eNOS, and insulin receptor\u2010\u03b2 were evaluated by Western blotting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TG, glucose, insulin levels, weight, WC\/TL ratio, HOMA index and resistin expression in penile tissue were significantly increased and ICP\/MAP values, and p (S1177) eNOS expression in penile tissue were decreased in MetS group. Boldine treatment enhanced ICP\/MAP values, insulin receptor\u2010\u03b2 and p(S1177) eNOS expressions compared with the MetS group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusion<\/jats:title><jats:p>MetS caused a deterioration in erectile function accompanied by an increase in resistin expression and a reduction in eNOS enzyme activation in the rat penile tissues. Boldine treatment resulted in an improvement in erectile function, independent of resistin expression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.12853","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T14:25:29Z","timestamp":1593613529000},"page":"1728-1735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The role of resistin on metabolic syndrome\u2010induced erectile dysfunction and the\u00a0possible therapeutic effect of Boldine"],"prefix":"10.1111","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0920-7660","authenticated-orcid":false,"given":"Erkan","family":"Kara","sequence":"first","affiliation":[{"name":"Department of Pharmacology Faculty of Medicine Dokuz Eylul University Izmir 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