{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:51:47Z","timestamp":1780339907747,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T00:00:00Z","timestamp":1594512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Penile cancer represents a rare pathology whose natural history of treatment is poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To illustrate the dynamic survival profiles in surgically treated patients with squamous cell carcinoma of the penis (SCCP) using the conditional survival (CS) estimates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Patients with non\u2010metastatic SCCP were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Conditional 3\u2010yr overall survival (OS) rate and 3\u2010yr cancer\u2010specific survival (CSS) rate represented the primary outcomes of interest and were calculated using the Kaplan\u2010Meier method. The multivariable Cox regression model was employed to calculate proportional hazard ratios for the prediction of mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1887 SCCP patients who had undergone surgeries were identified. Given a 1\u2010, 2\u2010, 3\u2010, 4\u2010, and 5\u2010yr survivorship, the 3\u2010yr OS rates were, respectively, improved by\u00a0+\u00a09.8 (72.6%), +18.2 (78.1%), +23.4 (81.6%), +27.8 (84.5%), and\u00a0+\u00a026.6% (83.7%) from those calculated at baseline (time zero). As compared with the baseline calculations, patients who had survived 1, 2, 3, 4, or 5\u00a0yr after surgery could, respectively, harvest a\u00a0+\u00a07.8 (84.7%), +14.8 (90.2%), +19.5 (93.9%), +22.1 (96.0%), and\u00a0+\u00a022.4% (96.2%) improvement in 3\u2010yr CSS. Patients with the most aggressive disease at baseline ultimately benefited the most from event\u2010free survivorship. Multivariable Cox regression analyses showed that the impact of adverse pathological parameters (G2\u20103, \u2265 pT2, pN+) on OS and CSS mostly showed a decreasing trend over time and some could disappear after a minimum of 1\u2010yr survivorship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and conclusion<\/jats:title><jats:p>The survival probability of SCCP patients increases with post\u2010operative survival. Patients with aggressive disease at baseline ultimately benefit the most from event\u2010free survivorship and may expect a better prognosis once they survive the critical few years after surgery. The recorded observations have crucial implications regarding patient counseling and follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.12856","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T16:37:30Z","timestamp":1593794250000},"page":"1744-1752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Conditional survival after surgery for patients with penile cancer"],"prefix":"10.1111","volume":"8","author":[{"given":"Wei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Urology Zhongnan Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongwen","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Urology Zhongnan Hospital of Wuhan University Wuhan 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