{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T09:16:00Z","timestamp":1770282960007,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>As COVID\u201019 infections wreak havoc across the globe, attention has rightly been focused on the vital organ systems (lung, kidney and heart) that are vulnerable to viral attack and contribute to the acute pathology associated with this disease. However, we should not lose sight of the fact that COVID\u201019 will attack any cell type in the body expressing ACE2 \u2010 including human spermatozoa. These cells possess the entire repertoire of receptors (AT1R, AT2R, MAS) and ligand processing enzymes (ACE1 and ACE2) needed to support the angiotensin signalling cascade. The latter not only provides COVID\u201019 with a foothold on the sperm surface but may also promote integration, given the additional presence of a range of proteases (TMPRSS2, TMPRSS11B, TMPRSS12, furin) capable of promoting viral fusion. This article reviews the roles played by these various cellular constituents in maintaining the vitality of human spermatozoa and their competence for fertilization. The reproductive consequences of a viral attack on these systems, in terms of fertility and the risk of sexual transmission, are currently unknown. However, we should be alive to the possibility that there may be reproductive consequences of COVID\u201019 infection in young males that go beyond their capacity to survive a viral attack.<\/jats:p>","DOI":"10.1111\/andr.12859","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T14:29:05Z","timestamp":1594391345000},"page":"48-52","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["COVID\u201019 and human spermatozoa\u2014Potential risks for infertility and sexual transmission?"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9152-156X","authenticated-orcid":false,"given":"Robert John","family":"Aitken","sequence":"first","affiliation":[{"name":"Priority Research Centre for Reproductive Science Faculty of Science and Faculty of Health and Medicine University of Newcastle Callaghan NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,5]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.8292"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-020-0319-7"},{"key":"e_1_2_3_4_1","article-title":"Does COVID\u201019 affect male fertility?","volume":"1","author":"Abobaker A","year":"2020","journal-title":"World J Urol"},{"key":"e_1_2_3_5_1","article-title":"ACE2 receptor expression in testes: implications in COVID\u201019 pathogenesis","author":"Verma S","year":"2020","journal-title":"Biol Reprod"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08860-4"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.200601013"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmy017"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201600233"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-19-0274"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(89)80897-X"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2005.00326.x"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.113.114827"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1908736116"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.086967"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.22672"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161212799436593"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2007.11.015"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1998.275.1.E87"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.1998.tb01162.x"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2011.03.018"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.111.092528"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.11.004"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(96)00118-8"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.00062"},{"key":"e_1_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20110114"},{"key":"e_1_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00625.2018"},{"key":"e_1_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/8.9.817"},{"key":"e_1_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02202-13"},{"key":"e_1_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090665"},{"key":"e_1_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.2741\/4466"},{"key":"e_1_2_3_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01567-16"},{"key":"e_1_2_3_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00013.2020"},{"key":"e_1_2_3_34_1","article-title":"A single\u2010cell RNA expression map of human coronavirus entry factors","volume":"2020","author":"Singh M","year":"2020","journal-title":"BioRxiv"},{"key":"e_1_2_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30444-9"},{"key":"e_1_2_3_36_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1993.1114"},{"key":"e_1_2_3_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.11.024"},{"key":"e_1_2_3_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199412000-00005"},{"key":"e_1_2_3_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030876"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fandr.12859","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12859","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/andr.12859","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12859","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T19:03:11Z","timestamp":1693767791000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.12859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,5]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/andr.12859"],"URL":"https:\/\/doi.org\/10.1111\/andr.12859","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,5]]},"assertion":[{"value":"2020-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}