{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:10:40Z","timestamp":1790392240723,"version":"4.1.0"},"reference-count":183,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Low testosterone (T) level is considered a marker of poor cardiovascular health. Ten years ago, the Testosterone in Older Men with Mobility Limitations (TOM) trial was discontinued due to a higher number of adverse events in men receiving T compared with placebo. Since then, several studies have investigated the risks of T replacement therapy (TRT) in late\u2010onset hypogonadism (LOH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To review the mechanism by which TRT could damage the cardiovascular system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Comprehensive literature search of recent clinical and experimental studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mechanisms of T\u2010mediated coronary vasodilation were reviewed with emphasis on calcium\u2010activated and ATP\u2010sensitive potassium ion channels. We showed how T regulates endothelial nitric oxide synthase (eNOS) and phosphoinositide 3\u2010kinase\/protein kinase B\/eNOS signaling pathways in vessel walls and its direct effects on cardiomyocytes via \u03b21\u2010adrenergic and ryanodine receptors and provided data on myocardial infarction and heart failure. Vascular smooth muscle senescence could be explained by the modulation of growth factors, matrix metalloproteinase\u20102, and angiotensin II by T. Furthermore, leukocyte trafficking, facilitated by changes in TNF\u2010\u03b1, could explain some of the effects of T on atheromatous plaques. Conflicting data on prothrombotic risk linked to platelet aggregation inhibition via NO\u2010triggered arachidonate synthesis or increased aggregability due to enhanced thromboxane A in human platelets provide evidence regarding the hypotheses on plaque maturation and rupture risk. The effects of T on cardiac electrophysiology and oxygen delivery were also reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The effects of TRT on the cardiovascular system are complex. Although molecular studies suggest a potential benefit, several clinical observations reveal neutral or occasionally detrimental effects, mostly due to confounding factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Attempts to demonstrate that TRT damages the cardiovascular system via systematic analysis of the putative mechanisms led to the contradiction of the initial hypothesis. Current evidence indicates that TRT is safe once other comorbidities are addressed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.12876","type":"journal-article","created":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T06:11:16Z","timestamp":1596262276000},"page":"1614-1627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Late\u2010onset hypogonadism: <i>Reductio ad absurdum<\/i> of the cardiovascular risk\u2010benefit of testosterone replacement therapy"],"prefix":"10.1111","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3850-627X","authenticated-orcid":false,"given":"Franz","family":"Sesti","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine \u201cSapienza\" University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7808-5735","authenticated-orcid":false,"given":"Riccardo","family":"Pofi","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine \u201cSapienza\" University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9091-2809","authenticated-orcid":false,"given":"Marianna","family":"Minnetti","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine \u201cSapienza\" University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7476-0737","authenticated-orcid":false,"given":"Marta","family":"Tenuta","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine \u201cSapienza\" University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2682-8266","authenticated-orcid":false,"given":"Daniele","family":"Gianfrilli","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine \u201cSapienza\" University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9037-5417","authenticated-orcid":false,"given":"Andrea M.","family":"Isidori","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine \u201cSapienza\" University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.2.7219"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1859"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.2.8201"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031719"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2006.00992.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1245"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0911101"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1796"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2011.12.005"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-39-1-40"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod31.4.785"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.122336"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.08.048"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-00229"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1972"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12705"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.4.683"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.7.1769"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0447"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1137"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2018.06.012"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-3580"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02339.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0262"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-014-0155-9"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv346"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)00112-1"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.9546"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000485"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.280386"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085805"},{"key":"e_1_2_6_33_1","unstructured":"US Food and Drug Administration.Drug safety communication: FDA cautions about using T products for low T due to aging requires labeling change to inform of possible increased risk of heart attack and stroke with use.https:\/\/www.fda.gov\/drugs\/drug\u2010safety\u2010and\u2010availability\/fda\u2010drug\u2010safety\u2010communication\u2010fda\u2010cautions\u2010about\u2010using\u2010testosterone\u2010products\u2010low\u2010testosterone\u2010due. Accessed June 10 2020."},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12770"},{"key":"e_1_2_6_35_1","unstructured":"Coordination Group for Mutual Recognition and Decentralised Procedures.Human (CMDh) position: No consistent evidence of an increased risk of heart problems with testosterone medicines.http:\/\/www.ema.europa.eu\/en\/documents\/referral\/testosterone\u2010article\u201031\u2010referral\u2010no\u2010consistent\u2010evidence\u2010increased\u2010risk\u2010heart\u2010problems\u2010testosterone_en.pdf. Accessed June 10 2020"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-6-8-549"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00880-7"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.13.1666"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.16.1906"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.021121"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0092"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.12.107"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.4.1154"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.10.2614"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/2042-6410-3-10"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.16.1690"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705141"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-12-0582"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.4.H1720"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fjc.0000161400.06704.1e"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-007-0213-3"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FP0060883"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.04.054"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-1243"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2006.11.003"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1780381"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20170090"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaq049"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-1048"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.10.061"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90127-9"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2003.51515.x"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00059.2005"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0052"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.3109\/08037051.2012.732777"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.12.010"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.05.065"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.09.114"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2004.06.018"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.09.070"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.055087"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-016-9910-5"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf160"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000125854.51637.06"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.052"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7262.2008.00335.x"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901073400103"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.628875"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01931.x"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.8881"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.21043"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.021824"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.708768"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1990440"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116670"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11871"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)03440-3"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052703199"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.17.2317"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031069"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.06779"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1664"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.180620"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00809.2013"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1993"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-199202000-00002"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1080\/00913847.1988.11709649"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.11.2742"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hci054"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2007.03.008"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2007.07.007"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-11-0441"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2018.1499886"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101438"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2019.08.011"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.10.023"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00083-6"},{"key":"e_1_2_6_108_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.014639"},{"key":"e_1_2_6_109_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi443"},{"key":"e_1_2_6_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.078"},{"key":"e_1_2_6_111_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/392432"},{"key":"e_1_2_6_112_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.015719"},{"key":"e_1_2_6_113_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.01845"},{"key":"e_1_2_6_114_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.931460"},{"key":"e_1_2_6_115_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00193.2008"},{"key":"e_1_2_6_116_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00054.2003"},{"key":"e_1_2_6_117_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00555.2012"},{"key":"e_1_2_6_118_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01251.2006"},{"key":"e_1_2_6_119_1","doi-asserted-by":"publisher","DOI":"10.1159\/000110444"},{"key":"e_1_2_6_120_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2009-0402"},{"key":"e_1_2_6_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2011.12.002"},{"key":"e_1_2_6_122_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.2003.01068.x"},{"key":"e_1_2_6_123_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0297"},{"key":"e_1_2_6_124_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000146900.84943.E0"},{"key":"e_1_2_6_125_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2000.109918"},{"issue":"7","key":"e_1_2_6_126_1","first-page":"690","article-title":"Sex differences in the evolution of the electrocardiographic QT interval with age","volume":"8","author":"Rautaharju PM","year":"1992","journal-title":"Can J Cardiol"},{"key":"e_1_2_6_127_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr172"},{"key":"e_1_2_6_128_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2009.00985.x"},{"key":"e_1_2_6_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.33"},{"key":"e_1_2_6_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.07.015"},{"key":"e_1_2_6_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2014.07.010"},{"key":"e_1_2_6_132_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e318225768b"},{"key":"e_1_2_6_133_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-474X.2012.00535.x"},{"key":"e_1_2_6_134_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu081"},{"key":"e_1_2_6_135_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.034282"},{"key":"e_1_2_6_136_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-00196"},{"key":"e_1_2_6_137_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2011.01163.x"},{"key":"e_1_2_6_138_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.523217"},{"issue":"3","key":"e_1_2_6_139_1","first-page":"395","article-title":"Modulation by testosterone of an endogenous hERG potassium channel current","volume":"59","author":"Ridley JM","year":"2008","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_6_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.09.012"},{"key":"e_1_2_6_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2006.09.003"},{"key":"e_1_2_6_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/206270a0"},{"key":"e_1_2_6_143_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197307122890205"},{"key":"e_1_2_6_144_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1692"},{"key":"e_1_2_6_145_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.9540"},{"key":"e_1_2_6_146_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-168032"},{"key":"e_1_2_6_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-351X(98)80248-6"},{"key":"e_1_2_6_148_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr288"},{"key":"e_1_2_6_149_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1784"},{"key":"e_1_2_6_150_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH05-06-0424"},{"key":"e_1_2_6_151_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt154"},{"key":"e_1_2_6_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2012.12.003"},{"key":"e_1_2_6_153_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12052"},{"key":"e_1_2_6_154_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025839"},{"key":"e_1_2_6_155_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.649426"},{"key":"e_1_2_6_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2008.12.011"},{"key":"e_1_2_6_157_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.2.526"},{"key":"e_1_2_6_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.51"},{"key":"e_1_2_6_159_1","doi-asserted-by":"publisher","DOI":"10.1159\/000176053"},{"key":"e_1_2_6_160_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-012-9725-9"},{"key":"e_1_2_6_161_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfr007"},{"issue":"3","key":"e_1_2_6_162_1","first-page":"256","article-title":"Testosterone deficiency increases hospital readmission and mortality rates in male patients with heart failure","volume":"105","author":"Santos MRD","year":"2015","journal-title":"Arq Bras Cardiol"},{"key":"e_1_2_6_163_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871530311313010011"},{"key":"e_1_2_6_164_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0553"},{"key":"e_1_2_6_165_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.111.965632"},{"key":"e_1_2_6_166_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00110"},{"key":"e_1_2_6_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.07.004"},{"key":"e_1_2_6_168_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338166"},{"key":"e_1_2_6_169_1","doi-asserted-by":"publisher","DOI":"10.1080\/07435800500406205"},{"key":"e_1_2_6_170_1","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.2043"},{"key":"e_1_2_6_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2006.04.006"},{"key":"e_1_2_6_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.122"},{"key":"e_1_2_6_173_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1997.0543"},{"key":"e_1_2_6_174_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114102"},{"key":"e_1_2_6_175_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00188.2003"},{"key":"e_1_2_6_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(86)90478-5"},{"key":"e_1_2_6_177_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00368.2014"},{"key":"e_1_2_6_178_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.2145"},{"key":"e_1_2_6_179_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2014.950653"},{"key":"e_1_2_6_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2018.04.641"},{"key":"e_1_2_6_181_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2005.05603.x"},{"key":"e_1_2_6_182_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0221"},{"key":"e_1_2_6_183_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506119"},{"key":"e_1_2_6_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30171-2"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fandr.12876","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12876","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/andr.12876","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12876","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T20:56:20Z","timestamp":1693601780000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.12876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,11]]},"references-count":183,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/andr.12876"],"URL":"https:\/\/doi.org\/10.1111\/andr.12876","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,11]]},"assertion":[{"value":"2020-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}