{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:03:34Z","timestamp":1790899414735,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cross\u2010sectional studies show that transgender people are more likely than cisgender people to experience depression and anxiety before gender\u2010affirming hormone treatment (GAHT). However, the effect of GAHT on mental health in transgender people, and the role of other factors that may have a predictive effect, is poorly explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Using a longitudinal methodology, this study investigated the effect of 18\u2010month GAHT on depression and anxiety symptomatology and the predictors on mental health outcomes in a large population of transgender people.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Participants (n\u00a0=\u00a0178) completed a socio\u2010demographic questionnaire, the Hospital Anxiety and Depression Scale (HADS), the Multidimensional Scale of Perceived Social Support (MSPSS) and the Autism Spectrum Quotient\u2014Short Version (AQ\u2010Short) at pre\u2010assessment (T0) and at 18\u00a0months after initiation of GAHT (T1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From T0 to T1, symptomatology was significantly decreased for depression (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and non\u2010significantly reduced for anxiety (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.37). Scores on the MSPSS predicted reduction in depression, while scores on the AQ\u2010Short predicted reduction in anxiety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>GAHT reduces symptoms of depression which are predicted by having higher levels of social support. Although anxiety symptoms also reduce, the changes are not significant and high levels of anxiety still remain post\u2010GAHT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results highlight the important mental health benefits of GAHT. Support services (professional, third sector or peer support) aiming at increasing social support for transgender individuals should be made available.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.12884","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T23:34:06Z","timestamp":1597102446000},"page":"1808-1816","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Long\u2010term effect of gender\u2010affirming hormone treatment on depression and anxiety symptoms in transgender people: A prospective cohort study"],"prefix":"10.1111","volume":"9","author":[{"given":"Zo\u00eb","family":"Aldridge","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences Institute of Mental Health University of Nottingham Nottingham UK"},{"name":"School of Sport, Exercise and Health Sciences Loughborough University Loughborough 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