{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:07Z","timestamp":1787013847097,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Platelet\u2010rich plasma is a biological instrument rich in growth factors and cytokines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to investigate the effect of platelet\u2010rich plasma on spermatogenesis and hormone production in an experimental testicular torsion model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>The rats were randomly divided into three groups, including six rats in each group as follows: the first group as the sham group; the second group as the ischemia\/reperfusion\u00a0+\u00a0Saline group and the third group as the ischemia\/reperfusion\u00a0+\u00a0platelet\u2010rich plasma group. The left testicles of the ischemia\/reperfusion\u00a0+\u00a0Saline and ischemia\/reperfusion\u00a0+\u00a0platelet\u2010rich plasma group were kept in four\u2010hour torsion. Then, the left testicles of ischemia\/reperfusion\u00a0+\u00a0Saline and ischemia\/reperfusion\u00a0+\u00a0platelet\u2010rich plasma groups were detorsioned, and intra\u2010testicular 1\u00a0cc saline (ischemia\/reperfusion\u00a0+\u00a0Saline) and 1\u00a0cc platelet\u2010rich plasma (ischemia\/reperfusion\u00a0+\u00a0platelet\u2010rich plasma) were injected. At one month, blood samples were taken from all groups for hormonal evaluation and left orchiectomy was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean follicle\u2010stimulating hormone level of ischemia\/reperfusion\u00a0+\u00a0Saline group was significantly higher than ischemia\/reperfusion\u00a0+\u00a0platelet\u2010rich plasma group (7.78\u00a0\u00b1\u00a00.23 vs 6.18\u00a0\u00b1\u00a00.28\u00a0nmol\/l, respectively,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.004). The mean LH level of ischemia\/reperfusion\u00a0+\u00a0platelet\u2010rich plasma group was significantly lower than ischemia\/reperfusion\u00a0+\u00a0Saline group (3.63\u00a0\u00b1\u00a00.28 vs 5.68\u00a0\u00b1\u00a00.21\u00a0nmol\/l, respectively,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.004). The mean total testosterone level of ischemia\/reperfusion\u00a0+\u00a0platelet\u2010rich plasma group was significantly higher than ischemia\/reperfusion\u00a0+\u00a0Saline group (8.05\u00a0\u00b1\u00a00.24 vs 5.78\u00a0\u00b1\u00a00.23\u00a0nmol\/l, respectively,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.004). The mean Johnsen scores of ischemia\/reperfusion\u00a0+\u00a0platelet\u2010rich plasma group were significantly higher than ischemia\/reperfusion\u00a0+\u00a0Saline group (5.85\u00a0\u00b1\u00a00.58 vs 3.93\u00a0\u00b1\u00a00.65, respectively,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.004). The mean Johnsen score of the sham group was significantly higher than ischemia\/reperfusion\u00a0+\u00a0platelet\u2010rich plasma and ischemia\/reperfusion\u00a0+\u00a0Saline groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.003 and\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.003, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and conclusion<\/jats:title>\n                    <jats:p>The platelet\u2010rich plasma has beneficial effects on spermatogenesis and reproductive hormone production in testicular torsion. It is easily accessible and applicable. In the future, intra\u2010testicular platelet\u2010rich plasma injection may be used in testicular torsion after detorsion. However, further experimental and large\u2010scale prospective clinical studies are needed to establish a definitive conclusion on this topic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.12895","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T15:14:56Z","timestamp":1598886896000},"page":"407-413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Effects of platelet\u2010rich plasma on spermatogenesis and hormone production in an experimental testicular torsion model"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7117-9210","authenticated-orcid":false,"given":"Musab Ali","family":"Kutluhan","sequence":"first","affiliation":[{"name":"Department of Urology Fatih Sultan Mehmet Training and Research Hospital Istanbul 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