{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:39:56Z","timestamp":1785299996841,"version":"3.55.0"},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The current outbreak of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection, named coronavirus disease 19 (COVID\u201019), is not the first well\u2010known spillover of an animal originated virus to infect humans. However, one of the few to make such a fast jump in a powerful evolutionary shortcut. The incredible pattern of aggressiveness worldwide since the beginning of the outbreak is that up to 20% of those infected need hospitalization and 5% evolve to critical conditions, not limited to respiratory\u2010related issues, but rather to systemic involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to summarize the current knowledge about the effects of SARS\u2010CoV\u20102 infection on the male genitourinary tract.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A narrative review was carried out to identify articles on the SARS\u2010CoV\u20102 infection on the male genitourinary system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Considerations were made about the molecular characteristics of SARS\u2010CoV\u20102 and immune response to coronavirus. We discussed the influence of the virus on the urinary system, potential mechanisms of COVID\u201019\u2010 related acute kidney injury (AKI), and the role of cytokine release syndrome on the renal pathophysiology of the disease. In the male reproductive tract, it was discussed the testis' vulnerability to SARS\u2010CoV\u20102 invasion and the possible adverse effects on its function and the seminal findings of COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and conclusion<\/jats:title><jats:p>During the COVID\u201019 pandemic, an international coordinated scientific effort must arise to understand the role of the urogenital system in the SARS\u2010CoV\u20102 infection in the clinical setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.12896","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T14:05:08Z","timestamp":1598969108000},"page":"73-79","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["SARS\u2010CoV\u20102 and its relationship with the genitourinary tract: Implications for male reproductive health in the context of COVID\u201019 pandemic"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6452-0502","authenticated-orcid":false,"given":"Jorge","family":"Hallak","sequence":"first","affiliation":[{"name":"Androscience, Science and Innovation Center in Andrology and High\u2010Complex Clinical and Andrology Research Laboratory S\u00e3o Paulo Brazil"},{"name":"Division of Urology University of S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Reproductive Toxicology Unit Department of Pathology University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6598-2442","authenticated-orcid":false,"given":"Thiago A.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Androscience, Science and Innovation Center in Andrology and High\u2010Complex Clinical and Andrology Research Laboratory S\u00e3o Paulo Brazil"},{"name":"Division of Urology University of S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Men\u2019s Health Study Group Institute for Advanced Studies University of S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Division of Urology, School of Medicine Federal University of Amap\u00e1 Amap\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4703-4270","authenticated-orcid":false,"given":"Felipe S.","family":"Bernardes","sequence":"additional","affiliation":[{"name":"Androscience, Science and Innovation Center in Andrology and High\u2010Complex Clinical and Andrology Research Laboratory S\u00e3o Paulo Brazil"},{"name":"Division of Urology University of S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Men\u2019s Health Study Group Institute for Advanced Studies University of S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Men\u2019s Health Study Group, Institute for Advanced Studies University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5767-5867","authenticated-orcid":false,"given":"Felipe","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Androscience, Science and Innovation Center in Andrology and High\u2010Complex Clinical and Andrology Research Laboratory S\u00e3o Paulo Brazil"},{"name":"Men\u2019s Health Study Group Institute for Advanced Studies University of S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Men\u2019s Health Study Group, Institute for Advanced Studies University of S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Department of Radiology University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0471-2729","authenticated-orcid":false,"given":"Sergio A. S.","family":"Duarte","sequence":"additional","affiliation":[{"name":"Androscience, Science and Innovation Center in Andrology and High\u2010Complex Clinical and Andrology Research Laboratory S\u00e3o Paulo Brazil"},{"name":"Division of Urology University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9194-5266","authenticated-orcid":false,"given":"Juliana R.","family":"Pariz","sequence":"additional","affiliation":[{"name":"Androscience, Science and Innovation Center in Andrology and High\u2010Complex Clinical and Andrology Research Laboratory S\u00e3o Paulo Brazil"},{"name":"Division of Urology University of S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Men\u2019s Health Study Group Institute for Advanced Studies University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1313-9680","authenticated-orcid":false,"given":"Sandro C.","family":"Esteves","sequence":"additional","affiliation":[{"name":"Department of Surgery (Division of Urology) University of Campinas (UNICAMP) Campinas Brazil"},{"name":"Androfert, Andrology and Human Reproduction Clinic Campinas Brazil"},{"name":"Faculty of Health Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2026-6925","authenticated-orcid":false,"given":"Esper","family":"Kallas","sequence":"additional","affiliation":[{"name":"Department of Infectious and Parasitic Diseases University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2005-8253","authenticated-orcid":false,"given":"Paulo H. 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