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The safety and efficacy of conservative treatment for PD have not yet established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To provide the available information of the status of conservative therapy for PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic literature search was conducted using PubMed, EMBASE, and the Cochrane Library for English\u2010language journal articles between January 2000 and July 2019, using the terms \u201cConservative treatment for PD\u201d, \u201cmedical treatment for PD\u201d, \u201cnon\u2010invasive therapies for PD\u201d and \u201cminimally invasive therapies for PD\". This systematic review was conducted in agreement with the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) system. We also manually reviewed references from selected articles. The risk of bias in the included RCTs was assessed using the Cochrane Risk of Bias Assessment tool (RoB 2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Conservative treatment is accepted as the initial treatment step in most of the cases. This kind of therapy includes various methods of treatment such as medical, non\u2010invasive, and minimally invasive therapies. Ideal management of PD is not yet available. It is not possible to assess the value of treatment without well\u2010designed, randomized, placebo\u2010controlled, large\u2010scale clinical studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Optimistically, in the near future, we may witness emergence of efficacious new agents and modalities to revolutionize medical, non\u2010invasive, and minimally invasive treatment of this devastating condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.12927","type":"journal-article","created":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T12:16:55Z","timestamp":1603541815000},"page":"511-528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Medical, non\u2010invasive, and minimally invasive treatment for Peyronie\u2019s disease: A systematic review"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8671-5952","authenticated-orcid":false,"given":"Ahmed I.","family":"El\u2010Sakka","sequence":"first","affiliation":[{"name":"Department of Urology Suez Canal University Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/45.6.670"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000170231.51306.32"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2016.05.14"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67616-1"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/j.1939-4640.2001.tb02207.x","article-title":"Evaluation of nitric oxide synthase and arginase in the induction of a Peyronie\u2019s\u2010like condition in the rat","volume":"3","author":"Bivalacqua TJ","year":"2001","journal-title":"J Androl"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-1298(20)31417-6"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2019.01.001"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-194802000-00017"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2012.03003.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900414"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02549851"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000282228"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871528112666131205112432"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2012.00007.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2006.01270.x"},{"key":"e_1_2_5_18_1","first-page":"41","article-title":"Controlled clinic trial of vitamin E in Peyronie\u2019s disease","volume":"9","author":"Pryor JP","year":"1983","journal-title":"Prog Reprod Biol"},{"key":"e_1_2_5_19_1","first-page":"9","article-title":"Peyronie\u2019s disease. 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