{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:45:56Z","timestamp":1792035956564,"version":"4.4.0"},"reference-count":115,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T00:00:00Z","timestamp":1607644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The impact of human papillomavirus (HPV) on male fertility and associated reproductive outcomes has not been clarified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To elucidate the prevalence of seminal HPV infection and assess the associated effects on seminal parameters, male infertility, and reproductive outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis was performed in accordance with PRISMA guidelines. A search was performed using PubMed, MEDLINE, SCOPUS, and Cochrane databases. Studies published until November 2019 were included. HPV prevalence, risk of infertility, seminal parameters, and reproductive outcomes were evaluated among the general population and infertile men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty studies met the inclusion criteria. The prevalence of seminal HPV infection is significantly higher in infertile compared to the general population (20.9% versus 8.2%). A significant association between seminal HPV infection and male infertility (OR 3.30, 95% CI 1.87\u20135.84), even when adjusting for female infertility (OR 3.02, 95% CI\u00a0=\u00a02.11\u20134.33) was founded. In addition, HPV infection is related to a significant decrease in progressive motility (DM \u221210.35, IC \u221213.75, \u22126.96), a low sperm morphology score (DM \u22122.46, 95% CI \u22123.83, \u22121.08), and a significant increase in the sperm DNA fragmentation index (7.24, 95% CI 4.44.10.03) compared with HPV\u2010negative patients. It was also observed an increased risk of miscarriage (OR 5.13, 95% CI 2.40,10.94), and a reduced chance of ongoing pregnancy (OR 0.33, IC 95% 0.13,0,82) in patients undergoing ART with seminal HPV infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Infertile men have a higher prevalence of seminal HPV infection compared to the general population, regardless of the HPV genotype detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HPV in semen may have an impact in sperm quality and reproductive outcomes. Additional well\u2010designed studies are warranted to improve the quality of evidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.12948","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T14:20:47Z","timestamp":1605968447000},"page":"478-502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Seminal human papillomavirus infection and reproduction: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4921-1162","authenticated-orcid":false,"given":"Jose","family":"Moreno\u2010Sepulveda","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Department Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Cl\u00ednica de la Mujer Medicina Reproductiva Vi\u00f1a del Mar 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