{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T06:53:43Z","timestamp":1759042423427,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:00:00Z","timestamp":1612828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Male factor infertility (MFI) is a common medical condition which requires high\u2010quality research to guide clinical practice; however, systematic reviews (SRs) and meta\u2010analyses (MAs) often vary in quality, raising concerns regarding the validity of their results. We sought to perform an objective analysis of SRs and MAs in MFI treatment and management and to report on the quality of published literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive search in PubMed\/MEDLINE and Embase was used to identify relevant publications. Primary search terms were male infertility, male sterility, and male subfertility. Two authors independently performed searches, screened citations for eligibility, extracted data for analysis, and graded methodological quality using the validated AMSTAR (A Measurement Tool to Assess Systematic Reviews) instrument, a validated tool used in the critical appraisal of SRs\/MAs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 27 publications met inclusion criteria and were included in the analysis. Mean AMSTAR score (\u00b1 SD) among all publications was 7.4 (1.9) out of 11, reflecting \u201cfair to good\u201d quality. Non\u2010pharmacological medical treatment for MFI was the most commonly assessed intervention (n\u00a0=\u00a013, 48.1%). No publications met all AMSTAR criteria. While the number of SRs\/MAs has increased over time (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.037), the quality of publications has not significantly changed (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.72). SRs\/MAs of the Cochrane Library had higher AMSTAR score than non\u2010Cochrane SRs\/MAs (8.5 vs 6.3, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The methodological quality of SRs\/MAs should be assessed to ensure high\u2010quality evidence for clinical practice guidelines in MFI treatment and management. This review highlights a need for increased effort to publish high\u2010quality studies in MFI treatment and management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.12972","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T07:04:26Z","timestamp":1610694266000},"page":"801-809","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The quality of systematic reviews and meta\u2010analyses assessing the treatment and management of male infertility"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2127-2382","authenticated-orcid":false,"given":"Hriday P.","family":"Bhambhvani","sequence":"first","affiliation":[{"name":"Department of Urology Stanford University School of Medicine Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel R.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Department of Urology Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Eisenberg","sequence":"additional","affiliation":[{"name":"Department of Urology Stanford University School of Medicine Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09417-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2018.03.012"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.03.022"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-1591.91448"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000050950"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.05.150"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08729.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-7-10"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13653"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.05.085"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.03.127"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.03.044"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2019.01.009"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001350"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2008.10.009"},{"key":"e_1_2_9_17_1","first-page":"9","article-title":"Systematic reviews explained: AMSTAR\u2010how to tell the good from the bad and the ugly","volume":"12","author":"Sharif MO","year":"2013","journal-title":"Oral Health Dent Manag"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez101"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.10.025"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.175779"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12417"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.03.020"},{"key":"e_1_2_9_23_1","unstructured":"2016 Assisted Reproductive Technology National Summary Report.Centers for Disease Control and Prevention.https:\/\/www.cdc.gov\/art\/pdf\/2016\u2010report\/ART\u20102016\u2010National\u2010Summary\u2010Report.pdf(accessed 21 Aug 2020)."},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13754"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-017-0325-5"},{"key":"e_1_2_9_26_1","unstructured":"HigginsJPT LassersonT ChandlerJ ToveyD ChurchillR.Methodological Expectations of Cochrane Intervention Reviews (MECIR). Standards for the conduct and reporting of new Cochrane Intervention Reviews reporting of protocols and the planning conduct and reporting of updates. Cochrane: London 2016.https:\/\/methods.cochrane.org\/sites\/default\/files\/public\/uploads\/mecir_printed_booklet_final_v1.02.pdf(accessed 21 Aug 2020)."}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12972","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/andr.12972","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12972","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T05:20:17Z","timestamp":1693545617000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.12972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,9]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/andr.12972"],"URL":"https:\/\/doi.org\/10.1111\/andr.12972","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"type":"print","value":"2047-2919"},{"type":"electronic","value":"2047-2927"}],"subject":[],"published":{"date-parts":[[2021,2,9]]},"assertion":[{"value":"2020-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}