{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:27:50Z","timestamp":1785464870963,"version":"3.56.0"},"reference-count":78,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T00:00:00Z","timestamp":1615766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Publications of microsurgical testicular sperm extraction (mTESE) techniques and outcomes are heterogeneous, which may limit creation of best surgical practices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the quality and heterogeneity of published mTESE outcomes via a methodological analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials\/Methods<\/jats:title><jats:p>A systematic methodological analysis of all published literature on the use of mTESE in men with non\u2010obstructive azoospermia from 1999 to the July 2020 was performed. PubMed and MEDLINE searches were performed using the search terms \u201cmicrodissection TESE OR microsurgical TESE.\u201d Publications were evaluated on their reporting of pre\u2010operative factors, intraoperative techniques, surgical and clinical outcomes, and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010five studies met inclusion criteria. Surgical technique and sperm retrieval rates were the most reported criteria. Reporting on the presence of an embryologist intraoperatively was observed in approximately 30% of articles, while other procedural details including method of sperm quantification, quantity retrieved, and number of cryopreserved vials were observed in fewer than 10% of articles. Clinical outcomes, including pregnancy rates and live birth rates, were reported in fewer than 40% of the articles. Fetal outcomes including fetal and neonatal anomalies were rarely reported.\u00a0Fetal growth restriction, preterm delivery, small or large for gestational age, and NICU admissions were never reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There are inconsistencies in reporting quality of mTESE outcomes, specifically a lack of information on the quantity and quality of sperm retrieved, the role of embryology intraoperatively, and clinical outcomes, such as live birth rate and fetal anomalies. These gaps may guide development of standardized reporting guidelines to better assess and compare clinical outcomes across institutions and maintain focus on couples\u2010centric fertility outcomes in future mTESE studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.12997","type":"journal-article","created":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T15:01:00Z","timestamp":1615042860000},"page":"1108-1118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Evaluating the quality of reported outcomes for microsurgical TESE in men with non\u2010obstructive azoospermia: A methodological analysis"],"prefix":"10.1111","volume":"9","author":[{"given":"John","family":"Ernandez","sequence":"first","affiliation":[{"name":"Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Berk","sequence":"additional","affiliation":[{"name":"Division of Urology Brigham and Women's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Urology Brigham and Women's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramy","family":"Abou Ghayda","sequence":"additional","affiliation":[{"name":"Department of Urology Case Western Reserve University Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2251-0461","authenticated-orcid":false,"given":"Martin","family":"Kathrins","sequence":"additional","affiliation":[{"name":"Division of Urology Brigham and Women's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-015-0032-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2017.07.07"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)38662-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12522-016-0234-z"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2013.00148.x"},{"issue":"3","key":"e_1_2_8_7_1","first-page":"124","article-title":"Clinical comparison of conventional testicular sperm extraction and microdissection techniques for non\u2010obstructive azoospermia","volume":"3","author":"Ghalayini I","year":"2011","journal-title":"J Clin Med Res"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2004.12.059"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64575-2"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12460"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12428"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.1.131"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/HUMREP\/10.6.1457"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/10.1.148"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.01.003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40814-019-0544-0"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-9-79"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.07.1136"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.11.2278"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.2004.tb02767.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.2005.tb01083.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2004.10.009"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/014850190884354"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2490-6-9"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.01.049"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2008.02.022"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2007.00814.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60087-9"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.03.108"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.01.008"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq074"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.01.005"},{"issue":"3","key":"e_1_2_8_33_1","first-page":"124","article-title":"Clinical comparison of conventional testicular sperm extraction and microdissection techniques for non\u2010obstructive azoospermia","volume":"3","author":"Ghalayini","year":"2011","journal-title":"J Clin Med Res"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.03.004"},{"issue":"3","key":"e_1_2_8_35_1","first-page":"1","article-title":"Optimization of spermatogenesis\u2010regulating hormones in patients with non\u2010obstructive azoospermia and its impact on sperm retrieval: A multicentre study","volume":"111","author":"Hussein A","year":"2013","journal-title":"BJU Int"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11714.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3109\/19396368.2012.733059"},{"issue":"2","key":"e_1_2_8_38_1","first-page":"79","article-title":"Using fresh and frozen testicular sperm samples in couples undergoing ICSI\u2010MicroTESE Treatment","volume":"14","author":"Tavukcuoglu S","year":"2013","journal-title":"J Reprod Infertil"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-1208.117175"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2014.10.024"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12932"},{"issue":"4","key":"e_1_2_8_42_1","first-page":"421","article-title":"Outcomes of micro\u2010dissection TESE in patients with non\u2010mosaic Klinefelter\u2019s syndrome without hormonal treatment","volume":"8","author":"Ozveri H","year":"2015","journal-title":"Int J Fertil Steril"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.05.037"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12067"},{"issue":"6","key":"e_1_2_8_45_1","first-page":"2436","article-title":"Evaluation of microdissection testicular sperm extraction results in patients with non\u2010obstructive azoospermia: Independent predictive factors and best cutoff values for sperm retrieval","volume":"12","author":"Cetinkaya M","year":"2015","journal-title":"Urol J"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12428"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12152"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12558"},{"issue":"6","key":"e_1_2_8_49_1","first-page":"581","article-title":"Azoospermia type does not affect intracytoplasmic sperm injection results when microdissection testicular sperm extraction is performed","volume":"61","author":"Aydin T","year":"2016","journal-title":"J Reprod Med"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12642"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12281"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2017.02.04"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7796.204188"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17420-z"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12417"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kjms.2017.08.010"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13243"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12092"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.909026"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-018-0367-y"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13052"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12528"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13176"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13217"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060518809257"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.5152\/tud.2019.76009"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12610-019-0091-9"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.4103\/UA.UA_36_18"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1900232"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12767"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12679"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.4081\/aiua.2018.2.130"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmz028"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.03.026"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.06.001"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12067"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.05.019"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11485.x"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-8-24"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12997","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/andr.12997","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12997","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T08:17:21Z","timestamp":1693297041000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.12997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,15]]},"references-count":78,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/andr.12997"],"URL":"https:\/\/doi.org\/10.1111\/andr.12997","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,15]]},"assertion":[{"value":"2020-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}