{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:23:47Z","timestamp":1790742227108,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Low\u2010intensity extracorporeal shock wave therapy (ESWT) for the treatment of vasculogenic erectile dysfunction (ED) has emerged as a promising method directly targeting the underlying pathophysiology of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare outcomes in ED patients after ESWT and placebo treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Prospective randomized placebo\u2010controlled single\u2010blinded trial on 66 patients with mild ED. The study comprised a 4\u2010week washout phase, a 4\u2010week treatment phase, and a 48\u2010week follow\u2010up. Inclusion criteria included age between 18 and 75\u00a0years and diagnosis of mild ED (IIEF\u2010EF score\u00a0=\u00a017\u201325) being made at least six months prior to study inclusion and being confirmed by Penile Doppler ultrasonography (US) at baseline examination. Efficacy endpoints were changes from baseline in patient\u2010reported outcomes of erectile function (International Index of Erectile Function domain scores [IIEF\u2010EF]), as well as erection hardness and duration (Sexual Encounter Profile diary [SEP] and Global Assessment Questions [GAQ]). Safety was assessed throughout the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 66 enrolled patients were allocated to ESWT (<jats:italic>n<\/jats:italic>\u00a0=\u00a044) or placebo (<jats:italic>n<\/jats:italic>\u00a0=\u00a022). Mean age of ESWT and placebo group was 42.32\u00a0\u00b1\u00a09.88 and 39.86\u00a0\u00b1\u00a011.64 (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.374), respectively. Mean baseline IIEF\u2010EF scores of ESWT group and placebo were 20.32\u00a0\u00b1\u00a02.32 and 19.68\u00a0\u00b1\u00a01.55 respectively (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.34). At 3\u2010months follow\u2010up, mean IIEF\u2010EF scores were significantly higher in ESWT patients than in placebo patients (23.10\u00a0\u00b1\u00a02.82 vs. 20.95\u00a0\u00b1\u00a02.19, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003), and IIEF\u2010EF scores of ESWT patients remained high during the 6\u00a0months (22.67\u00a0\u00b1\u00a03.35 vs. 19.82\u00a0\u00b1\u00a01.56) follow\u2010up. The percentage of patients reporting both successful penetration (SEP2) and intercourse (SEP3) in more than 50% of attempts was significantly higher in ESWT\u2010treated patients than in placebo patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). A minimal clinically important difference between the IIEF\u00a0=\u00a0EF baseline and 3\u2010months follow\u2010up was found in 74% of ESWT and 36% of placebo. No serious adverse events were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusion<\/jats:title><jats:p>ESWT significantly improved the erectile function of relatively young patients with vasculogenic mild ED when compared to placebo and the beneficial effect of this treatment up to 6\u00a0months. These findings suggest that ESWT could be a useful treatment option in vasculogenic ED.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13007","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T11:50:37Z","timestamp":1617018637000},"page":"1571-1578","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["The impact of extracorporeal shock wave therapy for the treatment of young patients with vasculogenic mild erectile dysfunction: A prospective randomized single\u2010blind, sham controlled study"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4784-5209","authenticated-orcid":false,"given":"Mazhar","family":"Ortac","sequence":"first","affiliation":[{"name":"Urology Department Faculty of Medicine Istanbul University Istanbul 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