{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T16:15:15Z","timestamp":1774887315267,"version":"3.50.1"},"reference-count":60,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T00:00:00Z","timestamp":1621641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["F32 HD097932"],"award-info":[{"award-number":["F32 HD097932"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HHSN2752012002"],"award-info":[{"award-number":["HHSN2752012002"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HHSN275201300025I"],"award-info":[{"award-number":["HHSN275201300025I"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HHSN27520130024I"],"award-info":[{"award-number":["HHSN27520130024I"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HHSN27500005"],"award-info":[{"award-number":["HHSN27500005"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HHSN27500006"],"award-info":[{"award-number":["HHSN27500006"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K24 HL138632"],"award-info":[{"award-number":["K24 HL138632"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR0001881"],"award-info":[{"award-number":["UL1TR0001881"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR000423"],"award-info":[{"award-number":["UL1TR000423"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dimethandrolone (DMA) and 11\u03b2\u2010methyl\u201019\u2010nortestosterone (11\u03b2\u2010MNT) are two novel compounds with both androgenic and progestational activity that are under investigation as potential male hormonal contraceptives. Their metabolic effects have never been compared in men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Assess for changes in insulin sensitivity and adiponectin and compare the metabolic effects of these two novel androgens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials\/Methods<\/jats:title><jats:p>In two clinical trials of DMA undecanoate (DMAU) and 11\u03b2\u2010MNT dodecylcarbonate (11\u03b2\u2010MNTDC), oral prodrugs of DMA and 11\u03b2\u2010MNT, healthy men received drug, or placebo for 28\u00a0days. Insulin and adiponectin assays were performed on stored samples. Mixed model analyses were performed to compare the effects of the two drugs. Student's t test, or the non\u2010parametric Kruskal\u2010Wallis test as appropriate, was used to evaluate for an effect of active drug versus placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Class effects were seen, with decrease in HDL\u2010C and SHBG, and increase in weight and hematocrit, with no statistically significant differences between the two compounds. No changes in fasting glucose, fasting insulin, or HOMA\u2010IR were seen with either compound. There was a slight decrease in adiponectin with DMAU that was not seen with 11\u03b2\u2010MNTDC. An increase in LDL\u2010C was seen with 11\u03b2\u2010MNTDC but not with DMAU.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>There were no significant changes in insulin resistance after 28\u00a0days of oral administration of these novel androgens despite a mild increase in weight. There may be subtle differences in their metabolic impacts that should be explored in future studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Changes in metabolic parameters should be carefully monitored when investigating androgenic compounds.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13025","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T07:59:08Z","timestamp":1619596748000},"page":"1526-1539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of metabolic effects of the progestational androgens dimethandrolone undecanoate and 11\u03b2\u2010MNTDC in healthy men"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8200-2311","authenticated-orcid":false,"given":"Fiona","family":"Yuen","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Endocrinology The Lundquist Institute at Harbor\u2010UCLA Medical Center Torrance CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthi","family":"Thirumalai","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances A.","family":"Fernando","sequence":"additional","affiliation":[{"name":"Contraceptive Development Program Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6084-6604","authenticated-orcid":false,"given":"Ronald S.","family":"Swerdloff","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Endocrinology The Lundquist Institute at Harbor\u2010UCLA Medical Center Torrance CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter Y.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Endocrinology The Lundquist Institute at Harbor\u2010UCLA Medical Center Torrance CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngju","family":"Pak","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Endocrinology The Lundquist Institute at Harbor\u2010UCLA Medical Center Torrance CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Hull","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Endocrinology The Lundquist Institute at Harbor\u2010UCLA Medical Center Torrance CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachelle","family":"Bross","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Endocrinology The Lundquist Institute at Harbor\u2010UCLA Medical Center Torrance CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana L.","family":"Blithe","sequence":"additional","affiliation":[{"name":"Contraceptive Development Program Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill E.","family":"Long","sequence":"additional","affiliation":[{"name":"Contraceptive Development Program Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie T.","family":"Page","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Endocrinology The Lundquist Institute at Harbor\u2010UCLA Medical Center Torrance CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)58221-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002\u2010020447"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.81.11.8923869"},{"issue":"2","key":"e_1_2_9_5_1","first-page":"757","article-title":"Combined administration of levonorgestrel and testosterone induces more rapid and effective suppression of spermatogenesis than testosterone alone: a promising male contraceptive approach","volume":"81","author":"Bebb RA","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68614-5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003\u2010030107"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/aja.aja_2_18"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2018.10.003"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2017.01.001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02166"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.13.6.629"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2019.11.270"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e32835edb71"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2217\/clp.15.10"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(95)05673-4"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12328"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.04135"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2012.06.008"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2005-0005"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/658913"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/dbi17-0016"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt087"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.2005.tb02876.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M414231200"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-1524"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01528"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2007.11.009"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01452"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa032"},{"key":"e_1_2_9_31_1","unstructured":"YuenF ThirumalaiA SwerdloffRS et al.Short term metabolic effects of two novel oral androgens dimethandrolone undecanoate and 11\u03b2\u2010MNTDC \u2013 supplemental file.https:\/\/doi.org\/10.6084\/m9.figshare.13081829.v3"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP09031.OR"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/58.12.M1103"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0553"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12319"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2918"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403465101"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.9.2734"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2010.06.009"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.111.013169"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(99)90056-2"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1510415"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/57.7.M460"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0265"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.38.73"},{"issue":"2","key":"e_1_2_9_47_1","first-page":"561","article-title":"Metabolic and behavioral effects of high\u2010dose, exogenous testosterone in healthy men","volume":"79","author":"Bagatell CJ","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijan.1995.18.5.237"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/01485010701730880"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02339.x"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(90)90150-B"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa238"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.suppl_1.60"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218533"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.02081.x"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409065"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.05.013"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.13985"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.482570"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.110.011817"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa761"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.13025","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/andr.13025","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.13025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T19:36:22Z","timestamp":1692819382000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.13025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,22]]},"references-count":60,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/andr.13025"],"URL":"https:\/\/doi.org\/10.1111\/andr.13025","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,22]]},"assertion":[{"value":"2021-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}