{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:48:07Z","timestamp":1791229687423,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874088"],"award-info":[{"award-number":["81874088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Due to limited data on the pathogenesis of chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS) and the suboptimal therapeutic effect, the development of new and effective treatment modalities was needed urgently. Low\u2010intensity extracorporeal shock wave therapy (Li\u2010ESWT) has been reported for the treatment of CP\/CPPS. However, the underlying mechanism remains to be elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To interrogated the efficacy and the mechanism of Li\u2010ESWT in the treatment of CP\/CPPS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>According to different treatments, RWPE\u20101 cells (human prostate epithelial cells) were randomly divided into three groups: control group, LPS (lipopolysaccharide) group, or Li\u2010ESWT group (LPS\u2010induced RWPE\u20101 managed by Li\u2010ESWT). Following the Li\u2010ESWT treatment, the levels of oxidative stress were assayed. We then established a rat model of experimental autoimmune prostatitis (EAP) by injecting prostatic protein homogenate mixed with complete Freund's adjuvant. The Sprague\u2010Dawley rats were randomly divided into the control group, EAP group, or Li\u2010ESWT group. Von Frey Filament was used to quantify pelvic hyperalgesia in the rats. Prostates tissues from each group were collected for immunohistochemistry, oxidation stress, and Western blot analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Histological analysis showed reduced inflammation and expression of cytokines (TNF\u2010\u03b1, IL\u20101\u03b2, IL\u20106, COX\u20102, SP) in prostate tissues from the Li\u2010ESWT group compared with those from the EAP group (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Similarly, there was reduced pelvic pain and allergic symptoms in the Li\u2010ESWT group compared with the EAP group (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Besides, Li\u2010ESWT treatment could decrease oxidative stress in the prostate and in RWPE\u20101 cells, respectively (both\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Moreover, the Li\u2010ESWT upregulated the expression of CAT through the inhibition of phosphorylation of AKT\/FOXO1 signaling pathway.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Conclusions<\/jats:title>\n                    <jats:p>Li\u2010ESWT may reduce inflammation, oxidative stress, and pain in rats with autoimmunity\u2010induced prostatitis via the PI3 K\/AKT\/FOXO1 pathway. It implies that Li\u2010ESWT can present a potential therapeutic option for the treatment of CP\/CPPS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.13027","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T15:04:18Z","timestamp":1620486258000},"page":"1593-1602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Li\u2010ESWT treatment reduces inflammation, oxidative stress, and pain via the PI3K\/AKT\/FOXO1 pathway in autoimmune prostatitis rat models"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6169-5692","authenticated-orcid":false,"given":"Bin","family":"Feng","sequence":"first","affiliation":[{"name":"Institute of Urology Key Laboratory of Gansu Urological Diseases Gansu Nephro\u2010Urological Clinical Center Lanzhou University Second Hospital Lanzhou China"},{"name":"Department of Urology Gansu Provincial Hospital 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