{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:28:25Z","timestamp":1788406105603,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anti\u2010M\u00fcllerian hormone and inhibin B are produced by Sertoli cells. Anti\u2010M\u00fcllerian hormone secretion indicates an immature Sertoli cell state. Inhibin B serves as a marker of male fertility. Identification of markers reflecting the presence of germ cells is of particular relevance in trans persons undergoing gender\u2010affirming hormone therapy in order to offer individualized fertility preservation methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Serum and intratesticular inhibin B and anti\u2010M\u00fcllerian hormone values were assessed and related to clinical features, laboratory values, and germ cell numbers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Twenty\u2010two trans women from three clinics were included. As gender\u2010affirming hormone therapy, 10\u201312.5\u00a0mg of cyproterone acetate plus estrogens were administered. Height, weight, age, medication, and treatment duration were inquired by questionnaires. Serum luteinizing hormone, follicle\u2010stimulating hormone, testosterone, and estradiol were measured by immuno\u2010assays. Serum and intratesticular inhibin B and anti\u2010M\u00fcllerian hormone were measured by commercially available ELISAs. Spermatogonia were quantified as spermatogonia per cubic millimeter testicular tissue applying a morphometric analysis of two independent testicular cross\u2010sections per individual after MAGEA4 immunostaining.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with high inhibin B levels presented with a higher number of spermatogonia (*<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Furthermore, mean serum inhibin B was associated with low age (*<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), low follicle\u2010stimulating hormone (*<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), and low testosterone (*<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Serum anti\u2010M\u00fcllerian hormone, however, was not related to spermatogonial numbers. It correlated with high testosterone (*<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) and high follicle\u2010stimulating hormone (*<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) only. High intratesticular inhibin B was accompanied by high luteinizing hormone (*<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), high follicle\u2010stimulating hormone (**<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01), and high testosterone levels (**<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). Higher the intratesticular anti\u2010M\u00fcllerian hormone levels, the longer gender\u2010affirming hormone therapy was administered (*<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and conclusion<\/jats:title><jats:p>Serum inhibin B levels indicate the presence of spermatogonia, whereas anti\u2010M\u00fcllerian hormone seems not to be a reliable marker concerning germ cell abundance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13059","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T10:29:45Z","timestamp":1622802585000},"page":"1781-1789","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Serum and intratesticular inhibin B, AMH, and spermatogonial numbers in trans women at gender\u2010confirming surgery: An observational study"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9002-6746","authenticated-orcid":false,"given":"Florian","family":"Schneider","sequence":"first","affiliation":[{"name":"Institute of Reproductive and Regenerative Medicine Centre of Reproductive Medicine and Andrology University Hospital Muenster  Muenster Germany"},{"name":"Department of Clinical and Surgical Andrology Centre of Reproductive Medicine and Andrology University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Dabel","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Regenerative Medicine Centre of Reproductive Medicine and Andrology University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhild","family":"Sandhowe\u2010Klaverkamp","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Regenerative Medicine Centre of Reproductive Medicine and Andrology University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Neuhaus","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Regenerative Medicine Centre of Reproductive Medicine and Andrology University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7571-5313","authenticated-orcid":false,"given":"Stefan","family":"Schlatt","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Regenerative Medicine Centre of Reproductive Medicine and Andrology University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Kliesch","sequence":"additional","affiliation":[{"name":"Department of Clinical and Surgical Andrology Centre of Reproductive Medicine and Andrology University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Wistuba","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Regenerative Medicine Centre of Reproductive Medicine and Andrology University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-01658"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0895-8176"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.13022"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8050730"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10508-012-0012-x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.med.0000436184.42554.b7"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoaa016"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmz006"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0542"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(93)90204-8"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-70-1-23"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12597"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.02.020"},{"key":"e_1_2_11_15_1","first-page":"1","article-title":"Anti\u2010M\u00fcller\u2010hormone 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