{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:35:10Z","timestamp":1791956110195,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971379"],"award-info":[{"award-number":["81971379"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Icariside II (ICA II), an active flavonoid monomer, has been proven to restore post\u2010prostatectomy erectile dysfunction in rats; however, the high cost of extraction from natural plants limits the application of ICA II.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the therapeutic effect and possible mechanism of action of YS\u201010, a new flavonoid compound, which was designed and synthesized based on the structure of ICA II in a rat model in of cavernous nerve injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials\/methods<\/jats:title><jats:p>Eight of 32 adult male Sprague\u2010Dawley rats were selected as the normal control (NC) group and received vehicle treatment. The remaining rats were subjected to bilateral cavernous nerve injury (BCNI) and randomized into three groups: BCNI group, BCNI + ICA II group (2.5\u00a0mg\/kg\/day), and BCNI + YS\u201010 group (2.5\u00a0mg\/kg\/day). The total procedure lasted for 21 days, followed by a washout period of 3 days. All animals were evaluated for erectile function, and tissues were harvested for histopathological analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>It was observed that in YS\u201010 group, the ratio of intracavernous pressure (ICP) to mean arterial pressure (MAP) and the area under the ICP\/MAP curve were effectively enhanced. The maximum ICP\/MAP increased by 30% in the YS\u201010 group (0.86 \u00b1 0.085) compared with the BCNI group (0.66 \u00b1 0.058), which is close to 82% of the NC group (1.05 \u00b1 0.033). Histopathological changes demonstrated significant reduction of smooth muscle atrophy, collagen deposition, and endothelial and neural dysfunction after YS\u201010 treatment, which have no statistical differences compared with ICA II group. Additionally, high\u2010protein expression levels of \u03b2\u2010Catenin and cyclin D1 were observed in the treatment groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>YS\u201010, a novel synthesized flavonoid compound, could effectively improve erectile dysfunction in rats after BCNI by alleviating pathological impairments; this effect may associate with the upregulation of \u03b2\u2010Catenin and cyclin D1 in Wnt signaling pathway.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13065","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T14:55:53Z","timestamp":1623250553000},"page":"1893-1901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A novel flavonoid derivative of icariside II improves erectile dysfunction in a rat model of cavernous nerve injury"],"prefix":"10.1111","volume":"9","author":[{"given":"Sheng\u2010ji","family":"Gu","sequence":"first","affiliation":[{"name":"Molecular Biology Laboratory of Andrology Center Peking University First Hospital Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory of Andrology Center Peking University First Hospital Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010ming","family":"Yuan","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory of Andrology Center Peking University First Hospital Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0361-2737","authenticated-orcid":false,"given":"Zhong\u2010cheng","family":"Xin","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory of Andrology Center Peking University First Hospital Peking University  Beijing China"},{"name":"Male Reproductive and Sexual Medicine Department of Urology The Second Hospital Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8652-8807","authenticated-orcid":false,"given":"Rui\u2010li","family":"Guan","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory of Andrology Center Peking University First Hospital Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901250"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.01.012"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250100656"},{"issue":"2","key":"e_1_2_9_6_1","first-page":"678","article-title":"Sildenafil citrate for treatment of erectile dysfunction in men with type 1 diabetes. 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