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Specific conditions covered in the review are Peyronie's disease, premature ejaculation, and penile enlargement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A broad and comprehensive literature search included Medline, EMBASE, and the Cochrane Libraries, with no time restriction up to December 2020 and restricted to English language publications. Unpublished studies were not included. The study was registered as \u201cThe role of hyaluronic acid in andrology: A systematic review and meta\u2010analysis\u201d in PROSPERO with the ID CRD42021223416.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and conclusion<\/jats:title><jats:p>Hyaluronic acid is a valid choice for the treatment of Peyronie's disease in terms of the resolution of the acute phase of the disease and of contributing to stabilizing the disease as a bridge to potential surgery. Data, furthermore, suggest that hyaluronic acid is frequently associated with an overall clinical improvement, allowing the patient to resume normal sexual activity.<\/jats:p><jats:p>With regard to premature ejaculation, data suggests hyaluronic acid\u2010based treatments were effective in prolonging intra\u2010vaginal ejaculation time. Furthermore, hyaluronic acid was found to be safe and well\u2010tolerated, with main adverse events limited to local discomfort, ecchymosis, papule formation, and glans numbness, all of which were reported to resolve spontaneously.<\/jats:p><jats:p>Last, with regard to penile enlargement, the overall perception of experts is that hyaluronic acid may be an extremely well\u2010tolerated compound with potential for application in specific areas of male sexual health that are often neglected as compared to more common, and relatively simpler to treat, conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13083","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T16:41:22Z","timestamp":1627058482000},"page":"42-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Clinical use of hyaluronic acid in andrology: A review"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2252-4297","authenticated-orcid":false,"given":"Alessandro","family":"Zucchi","sequence":"first","affiliation":[{"name":"Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio Ildefonso","family":"Scroppo","sequence":"additional","affiliation":[{"name":"Department of Urology and Andrology Ospedale di Circolo and Macchi Foundation  Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2347-9504","authenticated-orcid":false,"given":"Paolo","family":"Capogrosso","sequence":"additional","affiliation":[{"name":"Department of Urology and Andrology Ospedale di Circolo and Macchi Foundation  Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0595-7165","authenticated-orcid":false,"given":"Andrea","family":"Salonia","sequence":"additional","affiliation":[{"name":"Urology dept. 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