{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:39:13Z","timestamp":1747183153985,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Impaired paternal genome expression may cause poor embryonic development after in vitro fertilization (IVF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the expression of male infertility on embryo morphokinetics using a time\u2010lapse incubator and its impact on IVF cycles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This retrospective cohort study followed patients from January 2017 to August 2019. Patients were divided according to the cause of infertility to male factor (study group) and unexplained infertility (control group) and further subdivided according to the severity of male infertility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A cohort of 462 patients who underwent IVF cycles, with a total of 3,252 embryos was evaluated. Intracytoplasmic sperm injection (ICSI) was conducted more often in the study group compared to the control group (94%\u00a0vs. 47%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001) and more embryos were discarded (47%\u00a0vs. 43%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.016). Treatment outcomes were comparable in both groups regardless of the severity of male infertility. T3\u2013T5 had a significant impact on embryo quality and more transfer and freeze compared to discard. Maternal age, number of aspirated oocytes, BMI, protocol used, and faster time to T3, T6 were significant in increasing chances of achieving pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The paternal genome may have an earlier impact on embryo development than previously surmised and may also account for faster morphokinetics. Faster embryo cleavage in male infertility IVF\u2010ICSI cycles may contribute to outcomes comparable to other causes of infertility, in terms of embryo quality and clinical pregnancy rate, despite lower sperm quality, even in cases of severe Oligo\u2010terato\u2010Astheno spermia (OTA).<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13133","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T11:13:40Z","timestamp":1638184420000},"page":"525-533","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Male genome influences embryonic development as early as pronuclear stage"],"prefix":"10.1111","volume":"10","author":[{"given":"Aviv","family":"Peer","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology IVF Unit Hillel Yaffe Medical Center  Hadera Israel"},{"name":"Ruth and Bruce Rappaport School of Medicine The Technion\u2010Institute of Technology  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuval","family":"Atzmon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; 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