{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T23:28:08Z","timestamp":1790465288709,"version":"4.1.0"},"reference-count":199,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Necrozoospermia is a condition found in 0.2%\u20130.4% of male infertility cases. The causes of necrozoospermia are multiple: they can be related to testicular and\/or post\u2010testicular damage. Additionally, these causes most often involve the production of reactive oxygen species (ROS) and\/or sperm DNA fragmentation (SDF) which can reduce the chances of spontaneous pregnancy or affect the outcome of assisted reproductive technologies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To focus on potential etiologies of necrozoospermia, its diagnosis and its therapeutic management especially before the employment of ICSI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Authors searched PubMed\/Medline, Web of Science, Cochrane Library, Google and Institutional websites for medical subheading terms and free text words referred to \u201cnecrozoospermia\u201d, \u201csperm vitality\u201d, \u201csperm viability\u201d, SDF and \u201cICSI\u201d.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 12 main etiologies of necrozoospermia responsible for either a decrease of sperm vitality, a mild, a moderate or a severe necrozoospermia. In case of a confirmed decreased vitality, a thorough check\u2010up should be conducted and if available, etiological treatment should be proposed. Therapeutic management could also include repeated ejaculations, drug treatments, the use of ICSI with ejaculated or surgically extracted spermatozoa in case of a non\u2010treatable necrozoospermia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and conclusion<\/jats:title><jats:p>The potential causes of necrozoospermia should be investigated because many of them could be corrected, thus avoiding the use of ICSI. Moreover, if ICSI procedure remains necessary, the therapeutic management of necrozoospermia could also improve the chances of success by reducing oxidative stress and\/or SDF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13172","type":"journal-article","created":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T04:53:44Z","timestamp":1646456024000},"page":"642-659","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Necrozoospermia: The tree that hides the forest"],"prefix":"10.1111","volume":"10","author":[{"given":"Ang\u00e8le","family":"Boursier","sequence":"first","affiliation":[{"name":"Institut de Biologie de La Reproduction\u2010Spermiologie\u2010CECOS H\u00f4pital Jeanne de Flandre  CHU Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agathe","family":"Dumont","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie Endocrinienne et M\u00e9decine de La Reproduction Assistance M\u00e9dicale \u00e0 La Procr\u00e9ation et Pr\u00e9servation de La Fertilit\u00e9 H\u00f4pital Jeanne de Flandre  Avenue Eug\u00e8ne Avin\u00e9e, CHU Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Boitrelle","sequence":"additional","affiliation":[{"name":"Service de Biologie de la Reproduction et de Cytog\u00e9n\u00e9tique Centre Hospitalier Poissy\u2010Saint\u2010Germain\u2010en\u2010Laye  Poissy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Prasivoravong","sequence":"additional","affiliation":[{"name":"Service d'Andrologie H\u00f4pital Huriez  CHU Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Lefebvre\u2010Khalil","sequence":"additional","affiliation":[{"name":"Institut de Biologie de La Reproduction\u2010Spermiologie\u2010CECOS H\u00f4pital Jeanne de Flandre  CHU Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffroy","family":"Robin","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie Endocrinienne et M\u00e9decine de La Reproduction Assistance M\u00e9dicale \u00e0 La Procr\u00e9ation et Pr\u00e9servation de La Fertilit\u00e9 H\u00f4pital Jeanne de Flandre  Avenue Eug\u00e8ne Avin\u00e9e, CHU Lille Lille France"},{"name":"Service d'Andrologie H\u00f4pital Huriez  CHU Lille Lille France"},{"name":"EA 4308 Gam\u00e8togen\u00e8se Et Qualit\u00e9 du Gam\u00e8te Universit\u00e9 de Lille Et CHU de Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8985-6061","authenticated-orcid":false,"given":"Anne\u2010Laure","family":"Barbotin","sequence":"additional","affiliation":[{"name":"Institut de Biologie de La Reproduction\u2010Spermiologie\u2010CECOS H\u00f4pital Jeanne de Flandre  CHU Lille Lille France"},{"name":"EA 4308 Gam\u00e8togen\u00e8se Et Qualit\u00e9 du Gam\u00e8te Universit\u00e9 de Lille Et CHU de Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a137433"},{"key":"e_1_2_11_3_1","volume-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen","author":"World Health Organization","year":"2021"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12983"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/19396368.2012.710869"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.9.2279"},{"issue":"1","key":"e_1_2_11_7_1","first-page":"3","article-title":"Apoptosis, oncosis, and necrosis. 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