{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T01:35:34Z","timestamp":1776476134965,"version":"3.51.2"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Testicular torsion\/detorsion can lead to severe testicular damage. The organ\u2010protective effect of remote ischemic postconditioning (RLIPost) against ischemia\/reperfusion injury has been characterized; however, it remains unknown whether RLIPost has a testicular protective effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Here, we tested the hypothesis that RLIPost can protect the testes in a rat model of testicular torsion\/detorsion in vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Male Sprague\u2013Dawley rats were assigned to sham\u2010operated, control, or remote liver and limb ischemic postconditioning\u2010treated groups. Testicular torsion\/detorsion was performed by 3\u00a0h of testicular torsion (720\u00b0 clockwise unilateral spermatic cord torsion), followed by 3\u00a0h of detorsion. For liver and limb ischemic postconditioning, four cycles of 5 min of liver or limb ischemia with 5\u2010min intermittent reperfusion stimuli were conducted at the onset of testicular reperfusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Liver and limb ischemic postconditioning significantly ameliorated ipsilateral and contralateral testicular swelling responses, preserved morphological integrity and spermatogenesis and inhibited testicular apoptosis. In addition, RLIPost enhanced the phosphorylation of AKT\/ERK1\/2\/GSK\u20103\u03b2\/STAT\u20103 in the ipsilateral testis while suppressing JNK activation in the ipsilateral and contralateral testes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and conclusion<\/jats:title>\n                    <jats:p>To the best of our knowledge, this study is the first to demonstrate the involvement of RLIPost in an animal model of testicular torsion\/detorsion. We showed that RLIPost protects both ipsilateral and contralateral testes against testicular torsion\/detorsion in vivo, via at least in part, the RISK and SAFE\u2010mediated signaling pathways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.13184","type":"journal-article","created":{"date-parts":[[2022,4,10]],"date-time":"2022-04-10T07:23:25Z","timestamp":1649575405000},"page":"973-983","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Protective effect of remote ischemic postconditioning in rat testes after testicular torsion\/detorsion"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3642-9610","authenticated-orcid":false,"given":"Zhaoyang","family":"Hu","sequence":"first","affiliation":[{"name":"Laboratory of Anesthesia and Critical Care Medicine National\u2010Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology Department of 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