{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:50:36Z","timestamp":1792212636653,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901472"],"award-info":[{"award-number":["81901472"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neurogenic erectile dysfunction (NED) caused by cavernous nerve (CN) injury is a typical complication after pelvic surgery, which lacks efficient treatments. Acetyl\u2010L\u2010carnitine (ALCAR) has been proven to promote nerve repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the effect and potential mechanism of ALCAR in the treatment of NED.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Thirty\u2010two rats were randomly divided into bilateral CN injury (BCNI) group, BCNI + lower\u2010dose ALCAR (50\u00a0mg\/kg\/day) group, BCNI + higher\u2010dose (100\u00a0mg\/kg\/day) group, and sham\u2010operated group. Erectile function was assessed 14 days after daily intraperitoneal injection of ALCAR or placebo. The penile tissues were gathered for subsequent histological and molecular biological analysis. Rat Schwann cell (SC) line S16 was used to verify the mechanism of ALCAR in vitro.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that the erectile function of the rats in the BCNI group was severely impaired, which was improved considerably in both BCNI+ALCAR\u2010LD and BCNI+ALCAR\u2010HD groups. Also, we observed decreased smooth muscle and increased collagen content in the corpus cavernosum in the BCNI group. The expressions of fibrosis markers transforming growth factor\u2010beta (TGF\u2010\u03b2), connective tissue growth factor (CTGF), and Smad 2\/3 were significantly up\u2010regulated in the BCNI group. The above changes were alleviated after the administration of lower and higher\u2010dose ALCAR. Meanwhile, the nitric oxide (NO)\/cyclic guanosine monophosphate pathway (cGMP) was promoted and the Ras homolog gene family member A (RhoA)\/Rho\u2010associated protein kinase (ROCK) pathway was inhibited in the corpus cavernosum of BCNI rats after ALCAR treatment, accompanied by increased neuronal nitric oxide synthase (nNOS) and down\u2010regulated tyrosine hydroxylase (TH). In vitro, ALCAR promoted the migration and proliferation of SC and increased the expression of 22\u2010kD peripheral myelin protein and nerve growth factor (NGF). Further, rats treated with ALCAR had high expression of ATF3 and S100 in the distal nerve tissues of the CN extrusion site.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and conclusion<\/jats:title>\n                    <jats:p>ALCAR could promote nerve repair and regeneration, inhibit penile fibrosis, and improve penile erection by promoting the proliferation and migration of SC and the secretion of NGF. Our study confirms that ALCAR may be a potential treatment strategy for NED.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.13187","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T10:23:26Z","timestamp":1649931806000},"page":"984-996","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Acetyl\u2010L\u2010carnitine improves erectile function in bilateral cavernous nerve injury rats via promoting cavernous nerve regeneration"],"prefix":"10.1111","volume":"10","author":[{"given":"Jiaxin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Institute of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Institute of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoda","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Institute of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Urology Male Reproductive and Sexual Medicine The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiancheng","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Urology Male Reproductive and Sexual Medicine The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology Male Reproductive and Sexual Medicine The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongcheng","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Urology Male Reproductive and Sexual Medicine The Second Hospital of Tianjin Medical University  Tianjin China"},{"name":"Andrology Center Peking University First Hospital Peking University  Beijing China"},{"name":"China\u2010Korea Joint Research Center for Male Reproductive and Sexual Medicine Institute of Urology Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Institute of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taotao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Institute of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Institute of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Institute of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Institute of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaogang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Institute of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Institute of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7767-7309","authenticated-orcid":false,"given":"Yajun","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Institute of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5]]},"reference":[{"key":"e_1_2_18_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0b013e3283136462"},{"key":"e_1_2_18_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051389"},{"key":"e_1_2_18_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.03.024"},{"key":"e_1_2_18_5_1","doi-asserted-by":"publisher","DOI":"10.2741\/4459"},{"key":"e_1_2_18_6_1","doi-asserted-by":"publisher","DOI":"10.1139\/y71\u2010001"},{"key":"e_1_2_18_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20103940(89)90826\u20104"},{"key":"e_1_2_18_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1216100110"},{"key":"e_1_2_18_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2009.05.039"},{"key":"e_1_2_18_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.1.89"},{"key":"e_1_2_18_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450116666150316224456"},{"key":"e_1_2_18_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12522"},{"key":"e_1_2_18_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.01.097"},{"key":"e_1_2_18_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20475"},{"key":"e_1_2_18_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.227"},{"key":"e_1_2_18_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753193411426969"},{"key":"e_1_2_18_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.230297"},{"key":"e_1_2_18_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.00955.x"},{"key":"e_1_2_18_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.02.003"},{"key":"e_1_2_18_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2020.04.390"},{"key":"e_1_2_18_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2019.08.014"},{"key":"e_1_2_18_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2016.11.324"},{"key":"e_1_2_18_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41443\u2010020\u201000374\u20108"},{"key":"e_1_2_18_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.06.083"},{"key":"e_1_2_18_25_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1677\u201055382011000300007"},{"key":"e_1_2_18_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12228"},{"key":"e_1_2_18_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u2010410X.2008.07511.x"},{"key":"e_1_2_18_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0090\u20104295(02)02271\u20109"},{"key":"e_1_2_18_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900328"},{"key":"e_1_2_18_30_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.2013.814930"},{"key":"e_1_2_18_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0028\u20103908(02)00225\u20103"},{"key":"e_1_2_18_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.03.017"},{"key":"e_1_2_18_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esxm.2020.06.007"},{"key":"e_1_2_18_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13065"},{"key":"e_1_2_18_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sxmr.2018.02.007"},{"key":"e_1_2_18_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2003.11.002"},{"key":"e_1_2_18_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.06.094"},{"key":"e_1_2_18_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1083737"},{"key":"e_1_2_18_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2020.11.003"},{"key":"e_1_2_18_40_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119750"},{"key":"e_1_2_18_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166291"},{"key":"e_1_2_18_42_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712590903002047"},{"key":"e_1_2_18_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.10.013"},{"key":"e_1_2_18_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110405"},{"key":"e_1_2_18_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.07.001"},{"key":"e_1_2_18_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00033"},{"key":"e_1_2_18_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.10.023"},{"key":"e_1_2_18_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278\u20105846(94)00109\u2010u"},{"key":"e_1_2_18_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10327"},{"key":"e_1_2_18_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.07.026"},{"key":"e_1_2_18_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.10.025"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.13187","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/andr.13187","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.13187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T09:20:47Z","timestamp":1692868847000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.13187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/andr.13187"],"URL":"https:\/\/doi.org\/10.1111\/andr.13187","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742025860.793593069","asserted-by":"object"}]},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"2021-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}