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A multifactorial etiology of PD is assumed with diabetes mellitus (DM) being a potential risk factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this narrative review was to investigate diabetes role in PD pathophysiology, diagnosis, and treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A non\u2010systematic narrative review of original articles, meta\u2010analyses, and randomized trials was conducted, including articles in the pre\u2010clinical setting to support relevant findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Diabetes is one of the most common comorbidity observed in PD patients, with a prevalence of about 11% and a strong association with erectile dysfunction (ED). DM is associated with both a higher risk of developing PD and has also an impact on the outcomes of PD's treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Evidence from literature underlines that metabolic alterations typical of DM are pivotal factors in the development of PD and resistance to its medical treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The role of DM in development of PD is still debated, while its role in PD development is not completely clear, there is a clear impact of DM on PD treatment outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13224","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T16:54:52Z","timestamp":1656608092000},"page":"372-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Peyronie's disease development and management in diabetic 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