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The use of the latter has never decreased, jeopardizing the safety of workers and the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our purpose was to summarize the results of studies discussing the association between pesticides and male fertility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature search was performed through MEDLINE via PubMed, Scopus, and Web of Science. Only human studies were considered. Semen parameters and DNA integrity were considered to evaluate the effect of pesticides on men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 64 studies that investigated their impact in terms of semen parameters (51 studies) and chromatin and DNA integrity (25 studies) were included. The most frequently affected parameters were total sperm count, sperm motility, and sperm morphology, although a reduction in ejaculate volume and concentration occur in several cases. A tangible worsening of semen quality was associated with organochlorines and organophosphates. Furthermore, pesticide exposure, especially pyrethroids, was related to a higher DNA fragmentation index and chromosome aneuploidy in most articles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The epidemiological evidence supports the association between pesticides and male fertility for workers and the exposed population in terms of semen quality, DNA fragmentation, and chromosome aneuploidy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13228","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T17:10:39Z","timestamp":1657127439000},"page":"1250-1271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["The environmental and occupational influence of pesticides on male fertility: A systematic review of human studies"],"prefix":"10.1111","volume":"10","author":[{"given":"Carlo","family":"Giulioni","sequence":"first","affiliation":[{"name":"Department of Urology Polytechnic University of Marche Region Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Maurizi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Sciences Polytechnic University of Marche Region, \u201cOspedali Riuniti\u201d University Hospital Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Castellani","sequence":"additional","affiliation":[{"name":"Department of Urology Ospedali Riuniti\u201d University Hospital Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Scarcella","sequence":"additional","affiliation":[{"name":"Department of Urology Polytechnic University of Marche Region Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edlira","family":"Skrami","sequence":"additional","affiliation":[{"name":"Polytechnic University of Marche Region Centre of Epidemiology and Biostatistics Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Balercia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases Ospedali Riuniti\u201d University Hospital Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Benedetto","family":"Galosi","sequence":"additional","affiliation":[{"name":"Department of Urology Polytechnic University of Marche Region Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03105-9"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-1208.170370"},{"key":"e_1_2_11_4_1","unstructured":"Pesticides European Commission Pesticides.2021. 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