{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:06:18Z","timestamp":1781766378818,"version":"3.54.5"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Current studies have suggested a close link between nesfatin\u20101, an appetite\u2010related neuropeptide and gonadal hormones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We investigated the association between nesfatin\u20101 serum level and erectile dysfunction severity in men with diabetes as well as the generalized anxiety disorder\u20107 questionnaire, the patient health questionnaire\u20109, serum testosterone, kidney and liver functions, glycated haemoglobin and lipid profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Seventy\u2010five participants between 30 and 60 years were enrolled, 25 erectile dysfunction patients with type 2 diabetes (group I), 21 with diabetes and preserved erectile function (group II) and 29 healthy controls (group III). Erectile dysfunction status and severity were determined by the Arabic version of the international index of erectile function\u20105 for all the participants. Psychological wellbeing was checked by the generalized anxiety disorder\u20107 questionnaire and the patient health questionnaire\u20109. Finally, participants were evaluated for serum nesfatin\u20101, serum testosterone, kidney and liver functions, glycated haemoglobin and lipid profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum nesfatin\u20101 levels were significantly lower in groups I and II compared to the controls. The international index of erectile function\u20105 scores had shown significant correlations with serum nesfatin\u20101, serum testosterone, generalized anxiety disorder\u20107, patient health questionnaire\u20109, diastolic blood pressure, glycated haemoglobin, triglycerides, creatinine and albumin\/creatinine ratio. Receiver operating characteristic analysis revealed that serum nesfatin\u20101 \u2265 0.62 ng\/ml, serum testosterone \u22652.9 ng\/ml, generalized anxiety disorder\u20107 score \u22657.5, patient health questionnaire\u20109 score \u22655, glycated hemoglobin \u22656.4%, triglycerides \u2265 144\u00a0mg\/dl, creatinine \u2265 0.85\u00a0mg\/dl and albumin\/creatinine ratio \u2265 26.5 are useful predictors of erectile dysfunction in men with type 2 diabetes, and the area under the curve for those variables was respectively 0.83, 0.76, 1, 0.75, 0.88, 0.72, 0.67 and 0.77. Finally, a linear regression analysis revealed that generalized anxiety disorder\u20107 was the only strong independent predictor of the international index of erectile function\u20105 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and conclusion<\/jats:title><jats:p>Nesfatin\u20101 can be used as a biomarker for the severity of anxiety in erectile dysfunction patients with diabetes. Use of this molecule in treatment of diabetes and erectile dysfunction should be strengthened by larger studies. Psychiatric care must be offered to patients with diabetes and erectile dysfunction and low serum nesfatin\u20101 as they experience intense anxiety and depression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13237","type":"journal-article","created":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T05:08:16Z","timestamp":1658639296000},"page":"307-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Serum nesfatin\u20101 level in men with diabetes and erectile dysfunction correlates with generalized anxiety disorder\u20107: A prospective comparative study"],"prefix":"10.1111","volume":"11","author":[{"given":"Ahmed","family":"Ragab","sequence":"first","affiliation":[{"name":"Department of Andrology, Sexology and STDs Faculty of Medicine, Beni\u2010Suef University  Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud Hassan","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Medicine, Beni\u2010Suef University  Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Reda Sayed","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Molecular Biology Faculty of Medicine, Beni\u2010Suef University  Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia Adel Kamal","family":"EldinAbdelbary","sequence":"additional","affiliation":[{"name":"Egypt Ministry of Health and Population  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameh Fayek","family":"GamalEl Din","sequence":"additional","affiliation":[{"name":"Department of Andrology, Sexology and STDs Kasr Al\u2010Ainy Faculty of Medicine, Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60520-0"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00142.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13634"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijir.2008.42"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0302-2838(02)00005-2"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.02.020"},{"issue":"3","key":"e_1_2_12_8_1","first-page":"161","article-title":"Hyperlipidemia and erectile dysfunction","volume":"2","author":"Kim SC","year":"2000","journal-title":"Asian J Androl"},{"issue":"4","key":"e_1_2_12_9_1","first-page":"214","article-title":"The relationship between erectile dysfunction and cardiovascular disease. 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