{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:16:24Z","timestamp":1788992184397,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Extracorporeal shock wave therapy is an established treatment for erectile dysfunction and Peyronie's disease. Concerns regarding the safety of extracorporeal shock wave therapy for andrological purposes on testicular function were raised by animal studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the impact of extracorporeal shock wave therapy for erectile dysfunction or Peyronie's disease on reproductive and hormonal testicular function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We designed a prospective controlled study in which consecutive patients were enrolled. Males aged between 18 and 40\u00a0years with mild vasculogenic erectile dysfunction or acute inflammatory Peyronie's disease and normozoospermia were included. All enrolled patients were offered extracorporeal shock wave therapy, and subjects who refused extracorporeal shock wave therapy for any reason were considered as the Control group. All patients in the Intervention group were treated with DUOLITH SD1 T\u2010TOP by a single expert urologist. Semen analysis and serum total testosterone dosage were performed before the start (T0) and 3\u00a0months after the end of extracorporeal shock wave therapy (T1) in Intervention group. The same parameters were evaluated after the extracorporeal shock wave therapy refusal (T0) and at the end of the following 3\u00a0months (T1) in Control group. Normozoospermia was chosen as the primary outcome, serum total testosterone concentration was selected as the secondary outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 94 patients were enrolled in the study (48 Group A, 46 Group B). At T0, all patients were normozoospermic in both groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.563), and no significant difference in mean\u00a0\u00b1\u00a0SD total testosterone levels was recorded between the groups (582.5\u00a0\u00b1\u00a0107.2 vs. 634.6\u00a0\u00b1\u00a0108.4\u00a0ng\/dl; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.221). At T1, no significant deterioration (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05) in semen parameters was recorded in both groups. Only a statistically significant reduction in seminal pH was found after extracorporeal shock wave therapy compared to baseline (7.9\u00a0\u00b1\u00a00.3 vs. 7.5\u00a0\u00b1\u00a00.2; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and untreated patients (7.8\u00a0\u00b1\u00a00.2 vs. 7.5\u00a0\u00b1\u00a00.2; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). No significant difference in total testosterone levels was recorded in Intervention group after extracorporeal shock wave therapy compared to baseline (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.584).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Extracorporeal shock wave therapy in erectile dysfunction and Peyronie's disease patients does not seem to affect reproductive and hormonal testicular function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13240","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T05:24:35Z","timestamp":1659331475000},"page":"1368-1375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Impact of extracorporeal shockwave therapy for erectile dysfunction and Peyronie's disease on reproductive and hormonal testicular 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