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Owing to their stability, robustness and fast, easy and cost\u2010effective detection, microRNAs (miRNAs) are attractive candidate biomarkers to the clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Based on a comprehensive review of the relevant literature in the field, we explore the potential of miRNAs as biomarkers to answer relevant clinical dilemmas inherent to cancers of the male reproductive tract (prostate [PCa], testis [TGCTs] and penis [PeCa]) and identify some of the challenges\/limitations hampering their widely application.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and discussion<\/jats:title><jats:p>We conclude that the use of miRNAs as biomarkers is at different stages for these distinct cancer types. While for TGCTs, miRNA\u2010371a\u20103p is universally accepted to fill in important clinicals gaps and is moving fast towards clinical implementation, for PCa almost no overlap of miRNAs exists between studies, denoting the absence of a consistent miRNA biomarker, and for PeCa the field of miRNAs has just recently started, with only a few studies attempting to explore their clinical usefulness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Technological advances influencing miRNA detection and quantification will be instrumental to continue to move forward with implementation of miRNAs in the clinic as biomarkers for non\u2010invasive diagnosis, risk stratification, treatment monitoring and follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13258","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T15:24:19Z","timestamp":1659713059000},"page":"651-667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["MiRNA biomarkers in cancers of the male reproductive system: Are we approaching clinical application?"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3151-0367","authenticated-orcid":false,"given":"Vera","family":"Const\u00e2ncio","sequence":"first","affiliation":[{"name":"Cancer Biology and Epigenetics Group, Research Center of IPO Porto (CI\u2010IPOP)\/RISE@CI\u2010IPOP (Health Research Network) Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Centre (Porto.CCC)  Rua Dr. Ant\u00f3nio Bernardino de Almeida Porto Portugal"},{"name":"Doctoral Programme in Biomedical Sciences, School of Medicine 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