{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:23:04Z","timestamp":1792621384513,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diabetes mellitus\u2010induced erectile dysfunction (DMED) is one of the complications of diabetes and has a poor response to phosphodiesterase type 5 inhibitor, the first\u2010line treatment for ED. Saxagliptin (Sax), a dipeptidyl peptidase\u20104 inhibitor (DPP\u20104i), has been officially used in the treatment of type 2 diabetes. Stromal cell\u2010derived factor\u20101 (SDF\u20101) is one of the important substrates of DPP\u20104, and has been proven to be beneficial for several DM complications. However, it is unknown whether Sax contributes to the management of DMED.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To explore the effect and possible underlying mechanisms of Sax in the treatment of DMED.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The model of DM was established by intraperitoneal injection of streptozotocin. All rats were divided into three groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a08 per group): control group, DMED group and DMED+Sax group. In cellular experiments, the corpus cavernosum smooth muscle cells (CCSMCs) were exposed to high glucose (HG), and treated with Sax and AMD3100 (SDF\u20101 receptor inhibitor). The penile tissue and CCSMCs were harvested for detection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that erectile function was impaired in DMED rats compared with the control group, which was partially relieved by Sax. Decreased expression of DPP\u20104 and increased level of SDF\u20101 were also observed in DMED+Sax group, together with elevation of PI3K\/AKT pathway and inhibition of endothelial dysfunction, oxidative stress and apoptosis in corpus cavernosum. Moreover, Sax could also regulate oxidative stress and apoptosis in CCSMCs under HG condition, which was blocked in part by AMD3100.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sax could alleviate DMED through increasing SDF\u20101 and PI3K\/AKT pathway, in company with moderation of endothelial dysfunction, oxidative stress and apoptosis. Our findings indicated that DPP\u20104 is may be beneficial to the management of DMED.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.13296","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T18:59:43Z","timestamp":1663354783000},"page":"295-306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Saxagliptin alleviates erectile dysfunction through increasing stromal cell\u2010derived factor\u20101 in diabetes mellitus"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2889-4419","authenticated-orcid":false,"given":"Taotao","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Institute of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 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