{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T05:11:25Z","timestamp":1781932285817,"version":"3.54.5"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Premature ejaculation (PE) is still a tough problem in drug treatment. Many clinical trials have proven that traditional Chinese medicine (TCM) has a significant effect in the treatment of PE. This article aims to provide the latest evidence for the efficacy and safety of TCM combined with selective serotonin reuptake inhibitors (SSRIs) in the treatment of PE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We looked for randomized controlled trials (RCTs) from China National Knowledge Infrastructure, Wanfang, VIP Database, MEDLINE, PubMed, Web of Science, EMBASE, and Cochrane Library until June 30, 2022. STATA 15.1 software was used to analyze all data for this article. The quality of the included articles was evaluated using the Cochrane Reviewer's Handbook 5.3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Finally, we selected 16 high\u2010quality RCTs in our meta\u2010analysis, which containing 889 patients. Meta\u2010analysis suggested that, compared with SSRIs alone, combination of TCM with SSRIs increased significantly intravaginal ejaculation latencv time and the scores of ejaculation control ability, sexual life satisfaction, PE\u2010related distress, and communication difficulties between partners related to PE. Also, there was no significant difference in adverse effects between the two groups. In addition, the results of publication bias test showed that no significant bias occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combined use of TCM and SSRIs has significant effect in the treatment of PE compared with SSRIs monotherapy and was generally well tolerated. Due to the small sample size, multicenter and large sample RCT is still needed in the future to further confirm the effectiveness and safety of TCM combined with SSRIs in the treatment of PE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13307","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T04:53:26Z","timestamp":1664859206000},"page":"112-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Selective serotonin reuptake inhibitors combined with traditional Chinese medicine for premature ejaculation: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"11","author":[{"given":"Xuefeng","family":"Chang","sequence":"first","affiliation":[{"name":"Fuyang People's Hospital Anhui Medical University  Fuyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwei","family":"Xu","sequence":"additional","affiliation":[{"name":"The Affiliated Hongqi Hospital Mudanjiang Medical University  Mudanjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhe","family":"Chen","sequence":"additional","affiliation":[{"name":"Fuyang People's Hospital Anhui Medical University  Fuyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunguang","family":"Che","sequence":"additional","affiliation":[{"name":"Fuyang People's Hospital Anhui Medical University  Fuyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Du","sequence":"additional","affiliation":[{"name":"Fuyang People's Hospital Anhui Medical University  Fuyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2467-2752","authenticated-orcid":false,"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Fuyang People's Hospital Anhui Medical University  Fuyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2022.05.003"},{"issue":"3","key":"e_1_2_9_3_1","first-page":"120","article-title":"Premature ejaculation: from physiology to treatment","volume":"13","author":"Pereira\u2010Lourenco M","year":"2019","journal-title":"J Family Reprod Health"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000519930"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.14093"},{"issue":"10","key":"e_1_2_9_6_1","first-page":"933","article-title":"Progress in the treatment of premature ejaculation]","volume":"24","author":"Zhang JZ","year":"2018","journal-title":"Zhonghua Nan Ke Xue"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/aja.aja_122_18"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sxmr.2019.09.002"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.22655"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-018-0431-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.05.055"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2014.01.004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41443-018-0099-2"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-017-2086-5"},{"issue":"6","key":"e_1_2_9_15_1","first-page":"591","article-title":"SSRIs and SNRIs for premature ejaculation in adult men","volume":"105","author":"Sunder M","year":"2022","journal-title":"Am Fam Physician"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v17i3.2"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13915"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.2016.34.3.173"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015379"},{"issue":"7","key":"e_1_2_9_20_1","first-page":"650","article-title":"Medication rules of traditional Chinese medicine for the treatment of premature ejaculation: an analysis based on data mining","volume":"26","author":"Liu Y","year":"2020","journal-title":"Zhonghua Nan Ke Xue"},{"issue":"02","key":"e_1_2_9_21_1","first-page":"176","article-title":"Guidelines for diagnosis and treatment of premature ejaculation with integrated traditional Chinese and Western Medicine (trial version)","volume":"24","author":"Zhang JM","year":"2018","journal-title":"Nat J Androl"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2016.05.16"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"issue":"11","key":"e_1_2_9_25_1","first-page":"1050","article-title":"Clinical observation of Jinshuibao capsule combined with fluoxetine hydrochloride in the treatment of premature ejaculation","volume":"13","author":"Sun JM","year":"2007","journal-title":"Nat J Androl"},{"issue":"05","key":"e_1_2_9_26_1","first-page":"43","article-title":"Clinical study on the treatment of premature ejaculation with Yimusake tablets combined with fluoxetine hydrochloride","volume":"24","author":"Sun ZY","year":"2010","journal-title":"Chin J Androl"},{"issue":"04","key":"e_1_2_9_27_1","first-page":"437","article-title":"Efficacy of sertraline hydrochloride combined with compound Xuanju capsule in the treatment of premature ejaculation","volume":"33","author":"Liu YK","year":"2011","journal-title":"Guangxi J Med"},{"issue":"09","key":"e_1_2_9_28_1","first-page":"1082","article-title":"Efficacy analysis of gujing tang combined with paroxetine of treatment of premature ejaculation for 60 cases","volume":"37","author":"Sun J","year":"2013","journal-title":"J Guangzhou Univ Traditional Chin Med"},{"issue":"21","key":"e_1_2_9_29_1","first-page":"22","article-title":"Clinical effect of Yimusake tablets combined with paroxetine in the treatment of premature ejaculation","volume":"9","author":"Chen SQ","year":"2014","journal-title":"China Prac Med"},{"issue":"11","key":"e_1_2_9_30_1","first-page":"1010","article-title":"Clinical observation of Shugan Yiyang capsule combined with sertraline in the treatment of premature ejaculation","volume":"21","author":"Wu XW","year":"2015","journal-title":"Nat J Androl"},{"issue":"34","key":"e_1_2_9_31_1","first-page":"73","article-title":"Observation on treating 42 cases of prospermia with the Fufang Xuanju capsules plus sertraline","volume":"8","author":"Cai YL","year":"2016","journal-title":"Clinical J Chin Med"},{"issue":"10","key":"e_1_2_9_32_1","first-page":"42","article-title":"Clinical effect of Yimusak combined with dapoxefine in the treatment of premature ejaculation","volume":"30","author":"Cao HW","year":"2016","journal-title":"Chinese J Androl"},{"issue":"09","key":"e_1_2_9_33_1","first-page":"817","article-title":"Clinical observation of imazak tablets combined with dapoxetine hydrochloride in the treatment of primary premature ejaculation","volume":"22","author":"Yan XQ","year":"2016","journal-title":"Nat J Androl"},{"issue":"06","key":"e_1_2_9_34_1","first-page":"96","article-title":"Observation on the short\u2010term and long\u2010term effect of compound Xuanju capsule combined with dapoxetine hydrochloride in the treatment of premature ejaculation","volume":"14","author":"Peng XH","year":"2017","journal-title":"J Hunan Normal Univ(Med Sci)"},{"issue":"11","key":"e_1_2_9_35_1","first-page":"88","article-title":"Observation on the effect of sertraline combined with Yimusake treating premature ejaculation","volume":"26","author":"Liang GQ","year":"2017","journal-title":"Chin J Human Sex"},{"issue":"05","key":"e_1_2_9_36_1","first-page":"852","article-title":"Clinical study of modified Chaihu Shugan powder combined with dapoxetine in treatment of premature ejaculation with liver Qi stagnation syndrome","volume":"32","author":"Hai YB","year":"2017","journal-title":"Acta Chin Med"},{"issue":"03","key":"e_1_2_9_37_1","first-page":"23","article-title":"Clinical observation of tiaoganyishen decoction and paroxetine in the treatment of premature ejaculation","volume":"39","author":"Li DW","year":"2020","journal-title":"J Anhui Univ Traditional Chin Med"},{"issue":"04","key":"e_1_2_9_38_1","first-page":"38","article-title":"Clinical study on the treatment of primary premature ejaculation with Ningxin Anshen method combined with dapoxetine hydrochloride tablets","volume":"21","author":"Wang ZY","year":"2022","journal-title":"Bulletin Traditional Chin Med"},{"issue":"02","key":"e_1_2_9_39_1","first-page":"289","article-title":"Clinical observation on modified Wuzi Simiao prescription combined with sertraline in treating premature ejaculation of kidney deficiency and damp\u2010heat type","volume":"39","author":"He S","year":"2022","journal-title":"J Guangzhou Univ Traditional Chin Med"},{"issue":"06","key":"e_1_2_9_40_1","first-page":"31","article-title":"Clinical observation of Yougui capsule and Shugan Jieyu capsule combined with sertraline in the treatment of primary premature ejaculation of kidney deficiency and liver depression type","volume":"43","author":"Zhang ZL","year":"2022","journal-title":"Yunnan J traditional Chin Med"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13202"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01975.x"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2013.08.009"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41443\u2010021\u201000489\u20106"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esxm.2020.02.004"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2020.09.012"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343736"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12773"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12855"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/2090598X.2021.1943273"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13135"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.61.4.778"},{"issue":"06","key":"e_1_2_9_53_1","first-page":"119","article-title":"Comparison of Chinese and western medicine treatment strategy of premature ejaculation","volume":"31","author":"Dai HH","year":"2022","journal-title":"Chin J Human Sex"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-016-2456-7"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1418634"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.13307","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/andr.13307","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.13307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T11:08:10Z","timestamp":1692443290000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.13307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,13]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/andr.13307"],"URL":"https:\/\/doi.org\/10.1111\/andr.13307","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,13]]},"assertion":[{"value":"2022-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}