{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T08:32:46Z","timestamp":1747211566368,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Follicle\u2010stimulating hormone (FSH) receptor expression has been reported in many extra\u2010gonadal tissues, raising the question of non\u2010reproductive effects of FSH. Because of increasing usage of FSH in treatment of male infertility, deeper knowledge of possible harmful off\u2010target effects of FSH is warranted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 33 healthy young men (mean age 30 years) were included in the study. All received an s.c. injection of gonadotropin\u2010releasing hormone (GnRH) antagonist and <jats:italic>n<\/jats:italic>\u00a0=\u00a016 were randomized to 300 IU recombinant FSH (300 IE 3 times\/week) for 5\u00a0weeks at first visit (V1) whereas <jats:italic>n<\/jats:italic>\u00a0=\u00a017 served as controls. Blood samples were taken at (V1), after 3\u00a0weeks (V2), and after 5\u00a0weeks (V3), when the study ended. At V2, all subjects received 1000\u00a0mg testosterone undecanoate i.m. A standard set of bio\u2010 and inflammatory markers were compared between the groups using the Mann\u2013Whitney test adjusted for multiple testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As compared to controls, the FSH treated men had higher SHBG and albumin concentrations at V2 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.024 and 0.027, respectively), and lower levels of alanine aminotransferase (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.026) and magnesium (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.028) at V3. However, none of the results remained statistically significant after Bonferroni correction (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.0011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FSH had no significant effects on non\u2010reproductive organs when given in standard therapeutic doses to young men for 5 weeks. Therefore, the FSH treatment can be considered safe in otherwise healthy young men, constituting candidates for the infertility treatment with FSH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13335","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T12:28:21Z","timestamp":1669897701000},"page":"471-477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Non\u2010reproductive effects of follicle\u2010stimulating hormone in young men"],"prefix":"10.1111","volume":"11","author":[{"given":"Angel","family":"Elenkov","sequence":"first","affiliation":[{"name":"Reproductive Medicine Centre Skane University Hospital Malmo  Malm\u00f6 Sweden"},{"name":"Department of Translational Medicine Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elin","family":"Wirestrand","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine 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