{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T09:48:49Z","timestamp":1751881729451,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The COVID\u201019 is an ongoing health problem with millions of cases and deaths worldwide. Although the virus is transmitted with droplets through the respiratory system, the involvement of different organs has been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The pandemic caused urological procedures to be postponed when patient is infected with SARS\u2010CoV\u20102. However, the reliability of 1 month postpone period and long\u2010term complications of the virus, such as a possible erectile dysfunction (ED) is not clarified. We aimed to compare the corpus cavernosum of patients 1 and 7 months after COVID\u201019 infection with control patients who had not COVID\u201019 and search for SARS\u2010CoV\u20102 in tissues using immunohistochemistry and electron microscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Three groups of subjects underwent penile prosthesis implantation and Nesbit procedure for Peyronie's disease 1 and 7 months after COVID\u201019 infection and control group without previous COVID\u201019 infection. We searched for SARS\u2010CoV\u20102 in penile tissue using RT\u2010PCR, electron microscopy and immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Electron microscopy and immunohistochemical staining showed SARS CoV\u20102 virus in the penile corpus cavernosum of patients 1 month after COVID\u201019 recovery. Immunohistochemical staining intensity correlated with the severity of previous infection. Transmission electron microscopy revealed intracellular virtual particles of about 80\u00a0nm with a typical morphology of prominent spikes and electron\u2010dense dots of nucleocapsid in addition to vesicles filled with virus\u2010like particles. Cells showed increased membrane trafficking. The 1 month after COVID\u201019 group showed an increased number of fibroblasts. The 7 months after COVID\u201019 group had similar morphology and immunoreactivity as control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This is the first study of late post\u2010COVID examination of penis and the second study of early post\u2010COVID examination of corpus cavernosum. For 1 month post\u2010COVID patients, the aetiology of ED could be the viral infection that is also affecting corpora cavernosa. We hypothesize that viral infection affects the endocytic and exocytic pathways, hence the metabolic activity of cells that can be the reason of altered functions in some post\u2010COVID patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study is important because it did not detect any virus residue in the tissue samples at the seventh month. In addition, we can say that the penile surgeries should be postponed more than 1 month after the COVID infection according to this study. But, there is a need for new studies with large series and high levels of evidence that can show how long the virus remains in the corpus cavernosum. Patients should be followed in this respect.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13351","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T08:53:36Z","timestamp":1669366416000},"page":"1016-1022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evidence for residual SARS\u2010CoV\u20102 in corpus cavernosum of patients who recovered from COVID\u201019 infection"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3158-9300","authenticated-orcid":false,"given":"Elif","family":"Kervancioglu Demirci","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Dursun","sequence":"additional","affiliation":[{"name":"Department of Urology Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erva","family":"Sevi\u00e7","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u0131fat Burak","family":"Erg\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Urology Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"\u00d6nel","sequence":"additional","affiliation":[{"name":"Department of Microbiology Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"A\u011fa\u00e7fidan","sequence":"additional","affiliation":[{"name":"Department of Microbiology Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ate\u015f","family":"Kad\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Department of Urology Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,2]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"WHO. 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