{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:39:08Z","timestamp":1770424748089,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Peyronie's disease (PD) has a huge impact on patients\u2019 physical and psychological wellbeing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate whether patients\u2019 age has an impact on PD symptomatic burden at first presentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Data from 129 consecutive heterosexual patients seeking first medical attention for PD at a single andrological tertiary\u2010referral centre were collected. All patients completed the International Index for Erectile Function (IIEF) and the PD questionnaire (PDQ). Descriptive statistics were used to compare clinical features between younger (\u226440years) and older (&gt;40 years) patients. Multivariable linear model assessed the impact of age, the degree of penile curvature and their impact on PDQ (total scores and its domains), after adjusting for PD duration and IIEF\u2010erectile function domain scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 129, 24 (18.6%) patients were \u226440 years old. Young patients presented with a less severe curvature than older patients (median [interquartile ranges] 20\u00b0 [15\u201336] vs. 50\u00b0 [40\u201380]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04). However, younger age was associated with higher psychological and physical symptoms, PDQ\u2010penile pain and PDQ\u2010symptom bother scores (Coeff \u22120.11, \u22120.21 and \u22120.17, respectively) (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Moreover, the greater the degree of curvature, the higher the PDQ\u2013psychological and physical symptoms and the PDQ\u2010symptom bother scores (Coeff. 0.21 and 0.22, respectively; all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Around one in five men seeking first medical help for PD is younger than 40 years at presentation in the real\u2010life setting. PD\u2010related distress varies according to patients\u2019 age, with younger men presenting with a greater risk of penile pain and symptom bother despite lower curvature.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13352","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T08:26:57Z","timestamp":1669364817000},"page":"501-507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The symptomatic burden of Peyronie's disease at presentation according to patient age: A critical analysis of the Peyronie's disease questionnaire (PDQ) domains"],"prefix":"10.1111","volume":"11","author":[{"given":"Simone","family":"Cilio","sequence":"first","affiliation":[{"name":"Division of Experimental Oncology\/Unit of Urology URI IRCCS Ospedale San Raffaele  Milan Italy"},{"name":"Department of Neurosciences Reproductive Sciences and Odontostomatology Urology Unit University of Naples \u2018Federico 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