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Sexual symptoms, hormonal, metabolic, and instrumental (penile color Doppler ultrasound, PCDU) parameters were evaluated according to the reported habitual use of recreational substances (no use, 1\u20132 joints\/week, &gt;2 joints\/week, and use of illicit drugs other than cannabis).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When compared with non\u2010users, cannabis users were younger and exhibited a lower prevalence of comorbidities as well as better PCDU parameters, despite reporting higher alcohol and tobacco consumption. After adjustment for confounders, cannabis use was associated with a greater instability in the couple's relationship and a higher frequency of masturbation. In addition, the group smoking &gt;2 joints\/week showed a significantly lower body mass index than both controls and users of substances other than cannabis. Men who reported using recreational drugs (either cannabis or other) exhibited significantly lower levels of both total and low\u2010density lipoprotein cholesterol than non\u2010users. At the PCDU, smoking 1\u20132 joints\/week was associated with significantly higher dynamic peak systolic velocity than both non\u2010drug use and use of &gt;2 joints\/week. Prolactin levels were significantly higher in individuals smoking 1\u20132 joints\/week and in those who used substances other than cannabis when compared with controls, whereas no difference in total testosterone levels was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In men with sexual dysfunction, mild cannabis consumption may be associated with a more favorable anthropometric and lipid profile and with a better penile arterial vascular response to intracavernous prostaglandin injection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13382","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T06:55:00Z","timestamp":1673247300000},"page":"9-19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Is marijuana a foe of male sexuality? 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