{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:11:07Z","timestamp":1790385067132,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T00:00:00Z","timestamp":1674950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Contradictory data have been reported about the association between testosterone levels and the levels of low\u2010density lipoprotein cholesterol (LDL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to elucidate the association between testosterone and LDL levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study was conducted that included 7268 men who had participated in a health examination. Men who took agents that influence serum lipid profiles within the previous 6 months were excluded. A full metabolic work\u2010up and serum testosterone level checks were performed. The main outcome measures included the testosterone level and testosterone\u00a0&lt;3.5\u00a0ng\/ml prevalence of each decile of LDL and their polynomial trendlines and the odds ratio (OR) of testosterone\u00a0&lt;3.5\u00a0ng\/ml according to the LDL level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The polynomial trendline suggests the inverse association of testosterone with the deciles of triglycerides, the positive association of testosterone with the deciles of high\u2010density lipoprotein cholesterol and the inverted U\u2010shaped association between testosterone and the deciles of LDL. The polynomial trendline suggests a U\u2010shaped curvilinear relationship between the deciles of LDL and the prevalence of testosterone\u00a0&lt;3.5\u00a0ng\/ml. The adjusted ORs of testosterone\u00a0&lt;3.5\u00a0ng\/ml in men in the lowest and highest deciles were significantly higher than those of men in the 10th\u201390th deciles of LDL (OR [95% CI],\u00a0&lt;\u00a010th LDL: 1.4[1.2\u20131.8]; 10th \u2013 90th LDL: 1.0 [reference];\u00a0&gt;90th LDL: 1.3[1.0\u20131.6]), which reinforces the U\u2010shaped curvilinear relationship between LDL levels and the prevalence of testosterone\u00a0&lt;3.5\u00a0ng\/ml.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and conclusion<\/jats:title>\n                    <jats:p>Further research is needed to elucidate the association of very low or very high LDL concentrations with circulating testosterone in men.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.13393","type":"journal-article","created":{"date-parts":[[2023,1,22]],"date-time":"2023-01-22T06:23:30Z","timestamp":1674368610000},"page":"1107-1113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Non\u2010linear association between testosterone and LDL concentrations in men"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3567-0816","authenticated-orcid":false,"given":"Jun Ho","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Urology Nowon Eulji Medical Center Eulji University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuk\u2010Dal","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Urology Nowon Eulji Medical Center Eulji University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Duck","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Urology Nowon Eulji Medical Center Eulji University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Yoon","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Urology Nowon Eulji Medical Center Eulji University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tag Keun","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Urology Nowon Eulji Medical Center Eulji University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon Won","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Urology National Police Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.110.959247"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-018-0732-6"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.637793"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijir.2011.5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-0802"},{"key":"e_1_2_8_7_1","article-title":"Analysis of cardiovascular risk factors associated with serum testosterone levels according to the US 2011\u20132012 National Health and Nutrition Examination Survey","author":"Deng C","year":"2018","journal-title":"The Aging Male"},{"issue":"1","key":"e_1_2_8_8_1","first-page":"86","article-title":"Prospective association of low total testosterone concentrations with an adverse lipid profile and increased incident dyslipidemia","volume":"18","author":"Haring R","year":"2011","journal-title":"European Journal of Preventive Cardiology"},{"issue":"6","key":"e_1_2_8_9_1","first-page":"1610","article-title":"Relationship of sex hormones to lipids and lipoproteins in nondiabetic men","volume":"77","author":"Haffner SM","year":"1993","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.2.682"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.122624"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2018.08.006"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2011.12.005"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-019-1105-5"},{"key":"e_1_2_8_15_1","article-title":"Association between low density lipoprotein and all cause and cause specific mortality in Denmark: prospective cohort study","volume":"371","author":"Johannesen CDL","year":"2020","journal-title":"BMJ"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017635"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23705"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.190006"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12796"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.11.095"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14899"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12313"},{"issue":"10","key":"e_1_2_8_23_1","first-page":"73","article-title":"Androgens, cardiovascular disease and osteoporosis","volume":"28","author":"Isidori A","year":"2005","journal-title":"Journal of Endocrinological Investigation"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.7.7.1093"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02339.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(83)90743-3"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-019-0334-y"},{"key":"e_1_2_8_28_1","first-page":"2248","article-title":"Overview of OxLDL and its impact on cardiovascular health: focus on atherosclerosis","author":"Poznyak AV","year":"2021","journal-title":"Frontiers in Pharmacology"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-02751-z"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8598054"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-57"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.18565\/cardio.2014.2.37-42"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002642"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.13393","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/andr.13393","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.13393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T05:46:27Z","timestamp":1692251187000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.13393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,29]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/andr.13393"],"URL":"https:\/\/doi.org\/10.1111\/andr.13393","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,29]]},"assertion":[{"value":"2022-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}