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Recent meta\u2010analyses have indicated that obesity in men negatively affects basic sperm parameters such as sperm count, concentration and motility, increases the incidence of infertility and reduces the chances of conception. Sperm DNA damage, typically characterised by DNA strand breaks and oxidation of DNA nucleotides, is a specialised marker of sperm quality that has been independently associated with recurrent miscarriage, reduced assisted reproduction success and increased mutational loads in subsequent offspring. Whilst, there are still conflicting data in humans as to the association of obesity in men with sperm DNA damage, evidence from rodent models is clear, indicating that male obesity increases sperm DNA damage. Human data are often conflicting because of the large heterogeneity amongst studies, the use of body mass index as the indicator of obesity and the methods used for detection of sperm DNA damage. Furthermore, comorbidities of obesity (i.e., heat stress, adipokines, insulin resistance, changes in lipids, hypogonadism and obstructive sleep apnoea) are also independently associated with increased sperm DNA damage that is not always modified in men with obesity, and as such may provide a causative link to the discrepancies amongst human studies. In this review, we provide an update on the literature regarding the associations between obesity in men and fertility, basic sperm parameters and sperm DNA damage. We further discuss potential reasons for the discrepancies in the literature and outline possible direct and indirect mechanisms of increased sperm DNA damage resulting from obesity. Finally, we summarise intergenerational obesity through the paternal linage and how sperm DNA damage may contribute to the transmission.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13409","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T08:56:28Z","timestamp":1676451388000},"page":"1635-1652","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Sperm DNA damage: The possible link between obesity and male infertility, an update of the current literature"],"prefix":"10.1111","volume":"11","author":[{"given":"Andrew","family":"Peel","sequence":"first","affiliation":[{"name":"Robinson Research Institute The University of Adelaide  Adelaide South Australia Australia"},{"name":"Freemasons Centre for Male Health and Wellbeing The University of Adelaide  Adelaide South Australia Australia"},{"name":"Adelaide Health and Medical School School of Biomedicine Discipline of Reproduction and Development The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anmol","family":"Saini","sequence":"additional","affiliation":[{"name":"Robinson Research Institute The University of Adelaide  Adelaide South Australia Australia"},{"name":"Adelaide Health and Medical School School of Biomedicine Discipline of Reproduction and Development The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua C.","family":"Deluao","sequence":"additional","affiliation":[{"name":"Robinson Research Institute The University of Adelaide  Adelaide South Australia Australia"},{"name":"Freemasons Centre for Male Health and Wellbeing The University of Adelaide  Adelaide South Australia Australia"},{"name":"Adelaide Health and Medical School School of Biomedicine Discipline of Reproduction and Development The University of Adelaide  Adelaide South Australia 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