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This in turn results in a significant decrease in blood flow and perfusion of testicular tissue. During Testicular torsion, the testicular tissue is affected by ischemia, heat stress, hypoxia, and oxidative and nitrosative stress. The testicular torsion should be considered an emergency condition and surgical intervention (testicular detorsion ) as the sole treatment option in viable cases involves counter\u2010rotation on twisted testes associated, when possible, to orchipexy, in order to avoid recurrence. Possible testicular detorsion side\u2010effects occur due to reperfusion and endothelial cells injury, microcirculation disturbances, and intense germ cells loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To discuss testicular torsion surgery\u2010based methods, different time frames for testicular torsion induction, and the associated pathophysiology by emphasizing cellular and molecular events as well as different therapeutic agent applications for testicular torsion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>We reviewed all original research and epidemiological papers related to testicular torsion condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Testicular torsion causes germ cell necrosis, arrested spermatogenesis, and diminished testosterone levels, with consequent infertility. Among different involved pathophysiological impacts, testicular torsion\/detorsion\u2010induced ischemia seems to play the key role by leading the tissue toward other series of events in testis. Numerous studies have used adjuvant antioxidants, calcium channel blockers, anti\u2010inflammatory agents, or vasodilating agents in order to decrease these effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and conclusion<\/jats:title>\n                    <jats:p>To the best of our knowledge, no previously conducted study examined therapeutical agents' beneficial effects post clinical I\/R condition in humans. Different agents targeting different pathophysiological conditions were used to ameliorate the ischemia\/reperfusion\u2010induced condition in animal models, however, none of the administrated agents were tested in human cases. Although considering testicular detorsion surgery is still the golden method to reverse the testicular torsion condition and the surgical approach is undeniable, the evaluated agents with beneficial effects, need to be investigated furthermore in clinical conditions. Thus, furthermore clinical studies and case reports are required to approve the animal models proposed agents' beneficial impacts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.13418","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T06:09:31Z","timestamp":1677218971000},"page":"1267-1285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Testicular torsion in vivo models: Mechanisms and treatments"],"prefix":"10.1111","volume":"11","author":[{"given":"Aram","family":"Minas","sequence":"first","affiliation":[{"name":"Department of Surgery Division of Urology Human Reproduction Section S\u00e3o Paulo Federal University  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Mahmoudabadi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Faculty of Veterinary Medicine Shahid Chamran 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