{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:12:50Z","timestamp":1787166770867,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274517"],"award-info":[{"award-number":["82274517"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873307"],"award-info":[{"award-number":["81873307"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The causal relationship between obesity\u2010related anthropometric indicators\/body composition and erectile dysfunction has not been established in previous observational studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      We screened single nucleotide polymorphisms significantly associated with exposure from genome\u2010wide association studies as instrumental variables (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a05.0 \u00d7 10\n                      <jats:sup>\u22128<\/jats:sup>\n                      ). The summary statistics for erectile dysfunction were collected from a genome\u2010wide association study with a sample size of 223,805. Exposure and outcome populations included are of European ancestry. We used univariate and multivariate Mendelian randomization (i) to investigate the causal relationship between genetically predicted obesity\u2010related anthropometric indicators\/body composition and erectile dysfunction and (ii) to examine the mediating role of coronary artery disease. Mendelian randomization analysis was conducted using an inverse variance weighted method. A series of sensitivity analyses validated the results of the Mendelian randomization analysis. Causal estimates are expressed as odds ratios with 95% confidence intervals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Obesity\u2010related anthropometric indicators\/body composition were associated with an increased risk of erectile dysfunction in univariate Mendelian randomization analyses. For the 1\u2010SD increase in body mass index, the odds ratio was 1.841 (95% confidence interval: 1.049\u20131.355,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.006). For the 1\u2010SD increase in waist circumference and hip circumference, the odds ratios were 1.275 (95% confidence interval: 1.101\u20131.478,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001) and 1.156 (95% confidence interval: 1.015\u20131.317,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.009), respectively. The odds ratio for the 1\u2010SD increase in whole body fat mass was 1.221 (95% confidence interval: 1.047\u20131.388,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002). For the 1\u2010SD increase in leg fat percentage (left and right), the odds ratios were 1.256 (95% confidence interval: 1.006\u20131.567,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.044) and 1.285 (95% confidence interval: 1.027\u20131.608,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.028), respectively. For the 1\u2010SD increase in leg fat mass (left and right), the odds ratios were 1.308 (95% confidence interval: 1.108\u20131.544,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001) and 1.290 (95% confidence interval: 1.091\u20131.524,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003), respectively. For the 1\u2010SD increase in arm fat mass (left and right), the odds ratios were 1.269 (95% confidence interval: 1.113\u20131.447,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and 1.254, respectively. Multivariate Mendelian randomization analysis showed that after adjusting for coronary artery disease, some genetic predispositions to obesity\u2010related anthropometric indicators and body composition were still associated with an increased risk of erectile dysfunction. Significant associations were found for waist circumference\u2013erectile dysfunction (odds ratio: 1.218, 95% confidence interval: 1.036\u20131.432), leg fat percentage (left)\u2013erectile dysfunction (odds ratio: 1.245, 95% confidence interval: 1.035\u20131.497), leg fat mass (left)\u2013erectile dysfunction (odds ratio: 1.264, 95% confidence interval: 1.051\u20131.521), arm fat mass (right)\u2013erectile dysfunction (odds ratio: 1.186, 95% confidence interval: 1.024\u20131.373), and arm fat mass (left)\u2013erectile dysfunction (odds ratio: 1.17, 95% confidence interval: 1.018\u20131.360). Meanwhile, coronary artery disease mediated the effects of fat on erectile dysfunction, and the proportion of coronary artery disease\u2010mediated cases ranged from 10% to 22%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is a potential causal relationship between obesity\u2010related anthropometric indicators\/body composition and erectile dysfunction. Higher waist circumference, leg fat percentage, and arm fat mass may increase the risk of erectile dysfunction, and coronary artery disease partly mediates this overall effect. Understanding the causal relationship between obesity and erectile dysfunction and the mediating role of coronary artery disease may provide more information for erectile dysfunction intervention and prevention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.13443","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T03:38:49Z","timestamp":1682048329000},"page":"75-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of obesity\u2010related anthropometric indices and body composition on erectile dysfunction mediated by coronary artery disease: A Mendelian randomization study"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0915-5693","authenticated-orcid":false,"given":"Binghao","family":"Bao","sequence":"first","affiliation":[{"name":"Beijing University of Chinese Medicine China\u2010Japan Friendship Clinical 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