{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:05Z","timestamp":1787013845306,"version":"build-2736575974"},"reference-count":109,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:00:00Z","timestamp":1692316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Peyronie's disease (PD) is a connective tissue disorder affecting the tunica albuginea. It can cause pain and penile deformation, and its prevalence increases with age. Although surgery is the gold standard for the chronic phase of the disease, there are several conservative treatment methods available, and the optimal management of the acute phase of the disease remains a matter of debate. In this article, we aim to summarize the recent trends in research on the subject of non\u2010surgical treatment of PD. The search was performed in PubMed, Scopus, and Web of Science databases and included studies in English published between 2012 and 2022 investigating the clinical outcomes of non\u2010surgical PD management in humans. We have identified 20 distinct conservative treatment strategies. Among the oral therapeutics, only the use of phosphodiesterase type 5 inhibitors is currently recommended for clinical use in patients with concomitant erectile dysfunction. The use of collagenase from\n                      <jats:italic>Clostridium histolyticum<\/jats:italic>\n                      is supported by the best quality evidence in terms of intralesional injections for patients suffering from significant penile curvature; however, interferon alpha\u20102b can also be an option in such patients. Among other non\u2010invasive methods, extracorporeal shockwaves can be useful for pain reduction, and penile traction therapy can lead to a reduction in penile curvature and plaque size. Despite a wide range of non\u2010surgical methods available for PD treatment, the majority are not supported by sufficient scientific evidence, and the treatment efficacy is underwhelming. Further research on the subject of non\u2010surgical management of PD is highly warranted.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.13512","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T13:23:36Z","timestamp":1692624216000},"page":"505-517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Current trends in non\u2010surgical management of Peyronie's disease\u2014A narrative review"],"prefix":"10.1111","volume":"12","author":[{"given":"Anna","family":"Kozub","sequence":"first","affiliation":[{"name":"III<sup>rd<\/sup> Department of Radiotherapy and Chemotherapy Maria Sklodowska\u2010Curie National Research Institute of Oncology (MSCNRIO)  Gliwice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9208-6232","authenticated-orcid":false,"given":"Agata","family":"Suleja","sequence":"additional","affiliation":[{"name":"III<sup>rd<\/sup> Department of Radiotherapy and Chemotherapy Maria Sklodowska\u2010Curie National Research Institute of Oncology (MSCNRIO)  Gliwice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Ch\u0142osta","sequence":"additional","affiliation":[{"name":"Department of Urology Jagiellonian University Collegium Medicum  Krakow Poland"},{"name":"Department of Urology Comprehensive Cancer Center Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Kupilas","sequence":"additional","affiliation":[{"name":"Department of Urology and Urooncology City Hospital  Gliwice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Pradere","sequence":"additional","affiliation":[{"name":"Department of Urology Comprehensive Cancer Center Medical University of Vienna  Vienna Austria"},{"name":"Department of Urology University of Tours  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0556-3035","authenticated-orcid":false,"given":"Juan G\u00f3mez","family":"Rivas","sequence":"additional","affiliation":[{"name":"Department of Urology Hospital Cl\u00ednico San Carlos  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Rajwa","sequence":"additional","affiliation":[{"name":"Department of Urology Comprehensive Cancer Center Medical University of Vienna  Vienna Austria"},{"name":"Department of Urology Medical University of Silesia  Zabrze Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Miszczyk","sequence":"additional","affiliation":[{"name":"III<sup>rd<\/sup> Department of Radiotherapy and Chemotherapy Maria Sklodowska\u2010Curie National Research Institute of Oncology (MSCNRIO)  Gliwice Poland"},{"name":"Department of Radiation Oncology Comprehensive Cancer Center Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900877"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1743\u20106109.2007.00692.X"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SXMR.2019.06.004"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20105347(01)65367\u20109"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005392\u2010199701000\u201000103"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000127744.18878.f1"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/RRU.S65620"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20105347(01)65361\u20108"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20105347(01)64222\u20108"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20105347(05)67616\u20101"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/JSM.12731"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/IJIR.2015.22"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JURO.2013.01.087"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12368"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.UCL.2007.08.017"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2016.05.14"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JSXM.2019.03.404"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ESXM.2021.100459"},{"key":"e_1_2_13_20_1","unstructured":"SaloniaA BettocchiCCJ et\u00a0al.Sexual and Reproductive Health EAU Guidelines on Sexual and Reproductive Health. Published 2022. Published online2022:232."},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2020.1805865"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/BMJ.N71"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1365\u20102605.2011.01219.X"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871528112666131205112432"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871528111312010009"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/AND.12178"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047\u20102927.2012.00007.x"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EUF.2021.12.003"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JURO.2007.05.162"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EURURO.2005.10.026"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11845\u2010013\u20101036\u20105"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102605.2011.01226.x"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974\u20107796.152048"},{"issue":"1","key":"e_1_2_13_34_1","first-page":"25","article-title":"Evaluating the efficacy of intraplaque injection of dexamethasone with oral tadalafil in the chordee patients with Peyronie disease","volume":"10","author":"Hatampour M","year":"2022","journal-title":"Am J Clin Exp Urol"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1743\u20106109.2010.01790.X"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.5539\/gjhs.v6n7p23"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ESXM.2019.07.003"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/S40261\u2010019\u201000867\u20105"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0393\u20102249.18.03118\u20101"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.01.032"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41443\u2010020\u20100292\u2010y"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.UROLOGY.2018.06.049"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13932"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12497"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261\u2010020\u201000916\u20104"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2016.04.049"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000032"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41443\u2010018\u20100063\u20101"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2018.12.011"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCMA.0000000000000485"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/MSC.1144"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.13754"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010319\u201076735\u20102_6"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CARBPOL.2011.02.028"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168\u20103659(00)00300\u2010X"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esxm.2016.01.002"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.190108"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.5534\/WJMH.200048"},{"key":"e_1_2_13_59_1","first-page":"583","article-title":"Iloprost, a stable analogue of PGI2: clinical results and pathophysiological considerations","volume":"21","author":"Stock G","year":"1991","journal-title":"Adv Prostaglandin Thromboxane Leukot Res"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495\u2010199243060\u201000008"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u2010410X.2011.10733.x"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12896\u2010020\u201000605\u20102\/TABLES\/1"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.21037\/TAU.2016.03.15"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20105347(06)00517\u20109"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.4103\/UA.UA_65_17"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.05.022"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JURO.2015.06.096"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS21207794"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.purol.2022.05.004"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EJMECH.2009.09.047"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1677\u20105538.IBJU.2015.0598"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/00132580\u2010200101000\u201000008"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.4081\/aiua.2020.3.253"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/AND.13388"},{"issue":"8","key":"e_1_2_13_75_1","first-page":"745","article-title":"Transdermal iontophoresis with verapamil and dexamethasone in the acute phase of Peyronie's disease. Our experience","volume":"65","author":"Abad PG","year":"2012","journal-title":"Arch Esp Urol"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JSXM.2018.08.012"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.15171\/JLMS.2019.S7"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2015.03.010"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.5582\/IRDR.2019.01130"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.7556\/JAOA.2015.124\/MACHINEREADABLECITATION\/RIS"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13831"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14570"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SXMR.2018.02.005"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.36740\/WLEK202103129"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756287219838139"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/JSM.12400"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14602"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2020.10.003"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.2147\/RRU.S325929"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2017.01.054"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.UROLOGY.2012.12.030"},{"issue":"4","key":"e_1_2_13_92_1","first-page":"417","article-title":"Possibility of using the piezoelectric lithotriptor in the treatment of severe cavernous fibrosis","volume":"61","author":"Bellorofonte C","year":"1989","journal-title":"Arch Ital Urol Nefrol Androl"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.BLO.0000030173.56585.8F"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijir.2016.24"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12275"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.180100"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.4111\/kju.2015.56.11.775"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41443\u2010021\u201000447\u20102"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974\u20107796.192100"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.4103\/aja.aja_40_21"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JCONREL.2018.06.020"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2010.09.001"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00520\u2010016\u20103152\u2010Z\/TABLES\/1"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SURVOPHTHAL.2017.09.008"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSN.0000000000000273"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2021.0102"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860801910379"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2018.07.009"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2019.03.007"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.5534\/WJMH.2016.34.1.40"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.13512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T11:39:14Z","timestamp":1707824354000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.13512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,18]]},"references-count":109,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/andr.13512"],"URL":"https:\/\/doi.org\/10.1111\/andr.13512","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,18]]},"assertion":[{"value":"2023-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}