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According to epidemiological studies, environmental pollution (e.g., organic, inorganic, and air pollutants), occupational exposure (e.g., high temperature, organic solvents, and pesticides), and poor lifestyle (e.g., diet, sleep, smoking, alcohol consumption, and exercise) are important non\u2010genetic causative factors of MI. Due to multiple and complex causative factors, the dose\u2013effect relationship, and the uncertainty of pathogenicity, the pathogenesis of MI is far from fully clarified. Recent data show that the pathogenesis of MI can be monitored by the metabolites in serum, seminal plasma, urine, testicular tissue, sperm, and other biological samples. It is considered that these metabolites are closely related to MI phenotypes and can directly reflect the individual pathological and physiological conditions. Therefore, qualitative and quantitative analysis of the metabolome, the related metabolic pathways, and the identification of biomarkers will help to explore the MI\u2010related metabolic problems and provide valuable insights into its pathogenic mechanisms. Here, we summarized new findings in MI metabolomics biomarkers research and their abnormal metabolic pathways triggered by the presented non\u2010genetic risk factors, providing a metabolic landscape of semen and seminal plasma in general MI patients. Then, we compared the similarities and differences in semen and seminal plasma biomarkers between MI patients exposed to environmental and poor lifestyle factors and MI patients in general, and summarized some common biomarkers. We provide a better understanding of the biological underpinnings of MI pathogenesis, which might offer novel diagnostic, prognostic, and precise treatment approaches to MI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13530","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T03:40:01Z","timestamp":1697082001000},"page":"719-739","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A metabolomic perspective on the mechanisms by which environmental pollutants and lifestyle lead to male infertility"],"prefix":"10.1111","volume":"12","author":[{"given":"Wen","family":"Yang","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center Department of Obstetrics and Gynecology The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Reproductive Medicine Center Department of Obstetrics and Gynecology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9607-6605","authenticated-orcid":false,"given":"Rong","family":"Hua","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Department of Obstetrics and Gynecology The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Cao","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Department of Obstetrics and Gynecology The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojin","family":"He","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Department of Obstetrics and Gynecology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2018.03.012"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.03.022"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex234"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2016.25.18.S35"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-018-0003-3"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13586"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2021.06.007"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jes.2018.07.015"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2012.07.002"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.04.010"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2016.09.012"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu322"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.6.1554"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den399"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2017.98"},{"issue":"7","key":"e_1_2_10_17_1","first-page":"554","article-title":"Concepts in diagnosis and therapy for male reproductive impairment. 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