{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:39:56Z","timestamp":1773887996583,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R170\u20102014\u2010855"],"award-info":[{"award-number":["R170\u20102014\u2010855"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005275","name":"Region Hovedstaden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009780","name":"Region Sk\u00e5ne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000724","name":"Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000724","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011958","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["9039\u201000128B"],"award-info":[{"award-number":["9039\u201000128B"]}],"id":[{"id":"10.13039\/501100011958","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High parental age is associated with adverse birth and genetic outcomes, but little is known about fecundity in male offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We investigated if high parental age at birth was associated with biomarkers of male fecundity in a large population\u2010based sample of young men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We conducted a study of 1057 men from the Fetal Programming of Semen Quality (FEPOS) cohort, a sub\u2010cohort of sons born 1998\u20132000 into the Danish National Birth Cohort. Semen characteristics and reproductive hormone concentrations were measured in samples provided by the men 2017\u20132019. Testis volume was determined by self\u2010measurement. Data on the parental age was drawn from registers. Adjusted relative difference in percentage with 95% confidence intervals were estimated for each outcome according to pre\u2010specified maternal and paternal age groups (&lt;\u00a030 (reference), 30\u201334 and \u2265 35) as well as for combinations of parental age groups, using multivariable negative binomial regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We did not observe consistent associations between parental age and biomarkers of fecundity, although sons of mothers \u2265 35 years had lower sperm concentration (\u221215% (95% CI: \u221230, 3)) and total sperm count (\u221210% (95% CI: \u221225, 9)). The analysis with parental age combinations showed lower sperm concentration with high age of the parents (both \u2265 35 years: \u221227%, 95% CI: \u221240, \u221219) when compared to the reference where both parents were below 30 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and conclusion<\/jats:title><jats:p>We found no strong association between higher parental age and biomarkers of fecundity in young men. However, we cannot exclude poorer semen characteristics in sons born by older mothers or with high age of both parents.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13536","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T08:18:12Z","timestamp":1695716292000},"page":"89-100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Parental age at birth and biomarkers of fecundity in young Danish men"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5533-8891","authenticated-orcid":false,"given":"Andreas","family":"Ernst","sequence":"first","affiliation":[{"name":"Research Unit for Epidemiology, Department of Public Health Aarhus University  Aarhus Denmark"},{"name":"Department of Urology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nis","family":"Brix","sequence":"additional","affiliation":[{"name":"Research Unit for Epidemiology, Department of Public Health Aarhus University  Aarhus Denmark"},{"name":"Department of Clinical Genetics Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5242-939X","authenticated-orcid":false,"given":"Anne","family":"Gaml\u2010S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Research Unit for Epidemiology, Department of Public Health Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linn H\u00e5konsen","family":"Arendt","sequence":"additional","affiliation":[{"name":"Research Unit for Epidemiology, Department of Public Health Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Toft","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Aarhus Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7742-4360","authenticated-orcid":false,"given":"Sandra S\u00f8gaard","family":"T\u00f8ttenborg","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine Copenhagen University Hospital\u2010Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin S\u00f8ring","family":"Hougaard","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Copenhagen  Copenhagen Denmark"},{"name":"National Research Centre for the Working Environment  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens Peter Ellekilde","family":"Bonde","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine Copenhagen University Hospital\u2010Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia H\u00f8st","family":"Ramlau\u2010Hansen","sequence":"additional","affiliation":[{"name":"Research Unit for Epidemiology, Department of Public Health Aarhus University  Aarhus 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