{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:40:08Z","timestamp":1747183208704,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Little is known about patients\u2019 pre\u2010treatment expectations in Peyronie's disease (PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate in detail patients\u2019 expectations of conservative therapy and surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>This multi\u2010center study prospectively enrolled 317 PD patients, who were scheduled to receive conservative therapy or surgery between 2019 and 2022 at the Department of Urology of the University Medical Center Hamburg\u2010Eppendorf, and the Center of Reproductive Medicine and Andrology, University Medical Center Muenster, both Germany. The primary end\u2010point was patients\u2019 pre\u2010treatment expectations of conservative therapy and surgery, measured with the Stanford Expectations of Treatment Scale (SETS). Secondary end\u2010points included patient\u2010reported psychological and physical symptoms, penile pain, symptom bother and erectile function, measured with the Peyronie's disease questionnaire (PDQ) and International Index of Erectile Function Erectile Function Domain (IIEF\u2010EF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 239 (75%) and 78 (25%) patients were scheduled for the conservative therapy and surgery, respectively. Patients undergoing surgery had higher positive and negative mean SETS expectations scores (14\u00a0vs. 11, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001; 9.6\u00a0vs. 6.0, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). In multivariable analysis, surgery was an independent predictor of positive and negative patients\u2019 pre\u2010treatment expectations (all <jats:italic>p<\/jats:italic> \u2264 0.001). In thematic analysis, patients undergoing surgery emphasized distinct themes of pre\u2010treatment expectations. Patients undergoing surgery had higher mean PDQ symptom bother as well as higher psychological and physical symptom scores (14\u00a0vs. 10, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001; 9.2\u00a0vs. 7.1, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). There were significant positive correlations between SETS negative expectation score and PDQ symptom bother (|\u03c1|\u00a0=\u00a00.25; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) as well as PDQ psychological and physical symptoms score, respectively (|\u03c1|\u00a0=\u00a00.21; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PD patients expect both more benefit and more harm from surgery. In addition, patients undergoing surgery have more psychological and physical symptoms and more symptom bother. To set realistic expectations, it is of pivotal importance to assess patients\u2019 expectations before starting treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13538","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T11:49:24Z","timestamp":1695815364000},"page":"821-829","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["What do patients with Peyronie's disease expect from therapy? A prospective multi\u2010center study"],"prefix":"10.1111","volume":"12","author":[{"given":"Lukas","family":"Sch\u00e4fer","sequence":"first","affiliation":[{"name":"Department of Urology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jann F.","family":"Cremers","sequence":"additional","affiliation":[{"name":"Department of Clinical and Surgical Andrology Center of Reproductive Medicine and Andrology University Medical Center Muenster  Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahne","family":"Witschel","sequence":"additional","affiliation":[{"name":"Department of Urology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Sch\u00fcttfort","sequence":"additional","affiliation":[{"name":"Department of Urology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo O.","family":"Nieder","sequence":"additional","affiliation":[{"name":"Institute for Sex Research Sexual Medicine and Forensic Psychiatry University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Department of Urology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malte W.","family":"Vetterlein","sequence":"additional","affiliation":[{"name":"Department of Urology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Gild","sequence":"additional","affiliation":[{"name":"Department of Urology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Dahlem","sequence":"additional","affiliation":[{"name":"Department of Urology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margit","family":"Fisch","sequence":"additional","affiliation":[{"name":"Department of Urology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7561-4870","authenticated-orcid":false,"given":"Sabine","family":"Kliesch","sequence":"additional","affiliation":[{"name":"Department of Clinical and Surgical Andrology Center of Reproductive Medicine and Andrology University Medical Center Muenster  Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4552-4934","authenticated-orcid":false,"given":"Armin","family":"Soave","sequence":"additional","affiliation":[{"name":"Department of Urology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esxm.2021.100459"},{"key":"e_1_2_9_3_1","unstructured":"SaloniaA BettocchiC BoeriL et\u00a0al.European Association of Urology Guidelines on Sexual and Reproductive Health. 2023. 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